Ten cases of systemic lupus erythematosus related to hepatitis B vaccine

Agmon‐Levin, Nancy; Zafrir, Yaron; Paz, Ziv; Shilton, Tal; Zandman‐Goddard, Gisele; Shoenfeld, Yehuda

doi:10.1177/0961203309345732

Cited by 70 publications

(45 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Agmon-Levin and coworkers analyzed retrospectively the medical records of 10 SLE patients who developed the disease following HBV vaccination (20% after the first dose, 20% after the second dose, and 60% after the third dose) [90]. The mean latency period from the first HBV immunization and onset of autoimmune symptoms was 56.3 days.…”

Section: Hbv Vaccine and Systemic Lupus Erythematosusmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

View full text Add to dashboard Cite

Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

show abstract

Section: Hbv Vaccine and Systemic Lupus Erythematosusmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recently, a clinical syndrome referred to as 'autoimmune/ autoinflammatory syndrome induced by adjuvant' (ASIA), encompassing four different clinical entities, namely siliconosis [28,29], the 'gulf war syndrome' [30], macrophagic myofasciitis syndrome [31] and post-vaccination phenomena [29,[32][33][34], has been described in humans. The symptoms are overlapping and have been attributed to the probable effect of adjuvants (reviewed in [35][36][37][38]).…”

Section: Introductionmentioning

confidence: 99%

Effects of adjuvants for human use in systemic lupus erythematosus (SLE)-prone (New Zealand black/New Zealand white) F1 mice

Favoino

Favia

Digiglio

et al. 2013

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryThe safety of four different adjuvants was assessed in lupus-prone New Zealand black/New Zealand white ( Mean mouse weight at week 18 was lower in the ALU group than the IFA (Tukey's HSD post-test P = 0·04), CFA (P = 0·01) and SQU (P < 0·0001) groups, while the mean weight in the SQU group was higher than in the IFA (P = 0·009), CFA (P = 0·013) and UNT (P = 0·005) groups. The ALU group weight decreased by almost half between weeks 29 and 31, indicating some toxic effect of ALU in the late post-immunization period. Thus, SQU was the least toxic adjuvant as it did not (i) accelerate proteinuria onset compared to IFA; (ii) induce toxicity compared to ALU or (iii) elicit anti-RNP/Sm autoantibody, as occurred in the CFA group.

show abstract

“…A temporal link between SLE and HBV vaccination is the only relation that has been demonstrated [159].…”

Section: Systemic Lupus Erythematosus (Sle)mentioning

confidence: 99%

Vaccines, adjuvants and autoimmunity

Guimarães

Baker

Perricone

et al. 2015

Pharmacological Research

211

144

View full text Add to dashboard Cite

Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future.

show abstract

Ten cases of systemic lupus erythematosus related to hepatitis B vaccine

Cited by 70 publications

References 37 publications

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Effects of adjuvants for human use in systemic lupus erythematosus (SLE)-prone (New Zealand black/New Zealand white) F1 mice

Vaccines, adjuvants and autoimmunity

Contact Info

Product

Resources

About