Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population

Abstract

Purpose:To compare the cancer detection rate in patients with raised serum prostate-specific antigen (PSA) or abnormal digital rectal examination (DRE) results between the 10-core and the 16-core biopsy techniques in an Indian population.Methods:Between November 2010 and November 2012, 95 men aged >50 years who presented to the Urology Department with lower urinary tract symptoms, elevated serum PSA, and/or abnormal DRE findings underwent transrectal ultrasonography (TRUS)-guided prostate biopsy. A total of 53 patients underwent 10-core biopsy and 42 patients underwent 16-core biopsy.Results:Of the 53 men in the 10-core group, 8 had cancer, whereas in the 16-core biopsy group, 23 of 42 men had cancer. Detection of prostate cancer was significantly higher in patients who underwent 16-core biopsy than in those who underwent 10-core biopsy (P<0.001). Among the 95 men, 44 men had abnormal DRE findings (46.3%), of whom 23 showed cancer (52.27%). Of 51 men with normal DRE findings and elevated PSA, 8 men had malignancy with a cancer detection rate of 15.68%. Among 20 men with PSA between 4.1 and 10 ng/mL, 2 (10%) had cancer. In 31 men with PSA between 10.1 and 20 ng/mL, 3 cancers (9.67%) were detected, and in 44 men with PSA >20 ng/mL, 26 cancers were detected (59.09%).Conclusions:The cancer detection rate with 16-core TRUS-guided biopsy is significantly higher than that with 10-core biopsy (54.76% vs. 15.09%, P<0.001). In patients with both normal and abnormal DRE findings, 16-core biopsy has a better detection rate than the 10-core biopsy protocol. With increasing PSA, there is a high rate of detection of prostate cancer in both 10-core and 16-core biopsy patients.

A Comparative Study between Transrectal Ultrasound Guided 6-Core and 12-Core Prostate Biopsy for Detection of Prostate Cancer

“…Cancer detection rate was higher in both groups. Prakash et al, (2013) found higher cancer detection rate up to 59.09% in patients with PSA level greater than 20.1ng/ml [18]. In this study mean S. PSA >40 ng/ml.…”

Does it need to Take Digitally Targeted Biopsies Additionally to TRUS Guided 12- Core Systematic Prostate Biopsies? A Single Center Prospective Clinical Study

“…One of the drawbacks of 2 D TRUS evaluation is trajectories of the samples may not be visualized, therefore accurate mapping of the prostate may not be possible. Three dimensional TRUS guided biopsies provide tracking of each sample location and precise mapping, hence lessens duplicated biopsies as may be seen with two dimensional TRUS imaging [9].…”

Diagnosis of prostate cancer via nanotechnological approach

“…Currently available clinical diagnostic methods for prostate cancer include biochemical assay, [12][13][14][15][16][17][18][19][20] biopsy, [21][22][23][24][25][26][27] digital rectal examination (DRE), [28][29][30][31][32] and transrectal ultrasonography [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] as described in Figure 2. Among these methods, the biochemical assay is used for initial screening.…”

“…It can offer a visualization of the gland for examination and can be used to guide immediate, subsequent biopsies. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Upon detecting a suspicious portion of the gland, specimens are collected. Typically, 12 specimens are collected and evaluated according to the Gleason scoring system, and the most reliable, accurate diagnosis is finally made.…”