Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain

Zhang, Ming; Wang, Jian; Zhang, Kaixiang; Lu, Guozhen; Liu, Yuming; Ren, Keke; Wang, Wenting; Xin, Dazhuan; Xu, Lei; Mao, Honghui; Jin, Xing; Gao, Xingchun; Jin, Weilin; Berry, Kalen; Mikoshiba, Katsuhiko; Wu, Shengxi; Lü, Qing; Zhao, Xianghui

doi:10.1101/821496

Cited by 3 publications

(11 citation statements)

References 107 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lineage determination is also regulated by histone modifications, such as H3K27me3, which is catalyzed by the polycomb repressive complex 2 (PRC2) and is constituted of the enhancer of the zeste homolog 2 (EZH2) and embryonic ectoderm development (EED). EZH2 and EED are highly expressed in proliferating NSCs and target genes related to developmental processes and neurogenesis [ 91 , 92 ]. As NSCs differentiate into OPCs, EZH2 and EED expression remain high, while their levels decrease in cells transitioning to neuronal and astrocyte lineages [ 90 , 92 ].…”

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

“…EZH2 and EED are highly expressed in proliferating NSCs and target genes related to developmental processes and neurogenesis [ 91 , 92 ]. As NSCs differentiate into OPCs, EZH2 and EED expression remain high, while their levels decrease in cells transitioning to neuronal and astrocyte lineages [ 90 , 92 ]. Moreover, the ChIP-sequencing of H3K27me3 in postnatal-day-1 rat OPCs highlights its genomic regulation of genes involved in the “global alternative lineage choice” [ 93 ].…”

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

“…Moreover, the ChIP-sequencing of H3K27me3 in postnatal-day-1 rat OPCs highlights its genomic regulation of genes involved in the “global alternative lineage choice” [ 93 ]. Indeed, conditional ablation of Eed favors the differentiation into astroglial cells, to the detriment of the oligodendroglial lineage [ 92 ]. OPC lineage progression also depends on arginine methylation, as the conditional knockdown of Prmt1 in NSCs drastically reduces the number of OLs in mice [ 94 ].…”

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

“…However, the presence of DNA modification alone is not sufficient to induce precocious proliferation. Ablating DNMT1- or DNMT3A-mediated DNA methylation or EED-mediated histone methylation in OPCs does not result in ectopic proliferation in vitro or in vivo, and even slightly negatively perturbates OPC proliferation during development [ 87 , 92 , 133 ]. Inversely, TET1-mediated DNA hydroxymethylation does not seem to affect neonatal or adult OPC proliferation in vitro or in vivo [ 89 , 134 ].…”

Section: Epigenetic Marks Maintain An Oligodendroglial Progenitor mentioning

confidence: 99%

“…OPC differentiation is also dependent on marks that are generally associated with gene repression, such as histone methylation, deacetylation, and citrullination. Indeed, the ablation or inhibition of Prmt5 , Ezh2 , Eed , Hdac1/2 , or Padi2 in OPCs results in defective differentiation and myelination [ 55 , 92 , 93 , 121 , 132 , 135 , 137 , 143 , 155 , 156 , 157 , 159 ]. These marks mainly regulate the downregulation of OPC-specific inhibitors of differentiation (such as Id2/Id4 ) or cell cycle (such as Cdk4/6 , Cxcl2/5/10/14 ) genes, and therefore, are often essential for OPC cell cycle exits and early OL differentiation, but less involved in myelin maintenance [ 55 , 92 , 93 , 155 ].…”

Section: Epigenetic Marks Regulate the Oligodendroglial Progenitormentioning

confidence: 99%

See 4 more Smart Citations

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Pruvost

Moyon

2021

Life

View full text Add to dashboard Cite

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of oligodendroglial cell specification, proliferation, and myelination is required for correct neuronal connectivity and function. Here, we review the role of epigenetic modifications in oligodendroglial lineage cells. First, we briefly describe the epigenetic modalities of gene regulation, which are known to have a role in oligodendroglial cells. We then address how epigenetic enzymes and/or marks have been associated with oligodendrocyte progenitor specification, survival and proliferation, differentiation, and finally, myelination. We finally mention how environmental cues, in particular, neuronal signals, are translated into epigenetic modifications, which can directly influence oligodendroglial biology.

show abstract

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

Section: Epigenetic Marks With Roles In Oligodendroglial Cell Linementioning

confidence: 99%

Section: Epigenetic Marks Maintain An Oligodendroglial Progenitor mentioning

confidence: 99%

Section: Epigenetic Marks Regulate the Oligodendroglial Progenitormentioning

confidence: 99%

See 3 more Smart Citations

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Pruvost

Moyon

2021

Life

View full text Add to dashboard Cite

show abstract

DNA methylation in Schwann cells and in oligodendrocytes

Arthur‐Farraj

Moyon

2020

Glia

View full text Add to dashboard Cite

DNA methylation is one of many epigenetic marks, which directly modifies base residues, usually cytosines, in a multiple‐step cycle. It has been linked to the regulation of gene expression and alternative splicing in several cell types, including during cell lineage specification and differentiation processes. DNA methylation changes have also been observed during aging, and aberrant methylation patterns have been reported in several neurological diseases. We here review the role of DNA methylation in Schwann cells and oligodendrocytes, the myelin‐forming glia of the peripheral and central nervous systems, respectively. We first address how methylation and demethylation are regulating myelinating cells' differentiation during development and repair. We then mention how DNA methylation dysregulation in diseases and cancers could explain their pathogenesis by directly influencing myelinating cells' proliferation and differentiation capacities.

show abstract

Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases

Berry

Wang

2020

F1000Res

View full text Add to dashboard Cite

F1000 Faculty Reviews are written by members of the prestigious . They are F1000 Faculty commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. AbstractOligodendrocytes are the critical cell types giving rise to the myelin nerve sheath enabling efficient nerve transmission in the central nervous system (CNS). Oligodendrocyte precursor cells differentiate into mature oligodendrocytes and are maintained throughout life. Deficits in the generation, proliferation, or differentiation of these cells or their maintenance have been linked to neurological disorders ranging from developmental disorders to neurodegenerative diseases and limit repair after CNS injury. Understanding the regulation of these processes is critical for achieving proper myelination during development, preventing disease, or recovering from injury. Many of the key factors underlying these processes are epigenetic regulators that enable the fine tuning or reprogramming of gene expression during development and regeneration in response to changes in the local microenvironment. These include chromatin remodelers, histone-modifying enzymes, covalent modifiers of DNA methylation, and RNA modification-mediated mechanisms. In this review, we will discuss the key components in each of these classes which are responsible for generating and maintaining oligodendrocyte myelination as well as potential targeted approaches to stimulate the regenerative program in developmental disorders and neurodegenerative diseases. F1000Research 2020:105 Last updated: 11 FEB 2020 2. Boddaert N, Zilbovicius M, Philipe A, et al.: MRI findings in 77 children with nonsyndromic autistic disorder. PLoS One. 2009; 4(2): e4415. PubMed Abstract | Publisher Full Text | Free Full Text 3. Casanova MF: Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy. Neuroscientist. 2006; 12(5): 435-41. PubMed Abstract | Publisher Full Text 4. Deoni SCL, Zinkstok JR, Daly E, et al.: White-matter relaxation time and myelin water fraction differences in young adults with autism. Psychol Med. 2015; 45(4): 795-805. PubMed Abstract | Publisher Full Text 5. Hardan AY, Fung LK, Frazier T, et al.: A proton spectroscopy study of white matter in children with autism. Prog Neuropsychopharmacol Biol Psychiatry. 2016; 66: 48-53. PubMed Abstract | Publisher Full Text | Free Full Text 6. He D, Marie C, Zhao C, et al.: Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nat Neurosci. 2016; 19(5): 678-89. PubMed Abstract | Publisher Full Text | Free Full Text 7. Gregory LC, Gevers EF, Baker J, et al.: Structural pituitary abnormalities associated with CHARGE syndrome. J Clin Endocrinol Metab. 2013; 98(4): E737-43. PubMed Abstract | Publisher Full Text | Free Full Text 8. Popescu BF, Lucchinetti CF: Pathology of demyelinating diseases. Annu Rev Pathol. 2012; 7: 185-217. Pu...

show abstract

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain

Cited by 3 publications

References 107 publications

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

DNA methylation in Schwann cells and in oligodendrocytes

Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases

Contact Info

Product

Resources

About