Ten-month survival after lung homotransplantation in man

Transplantation milestones. Viewed with one- and two-way paradigms of tolerance

“…Over the ensuing 35 years, the beach-head has been expanded by the successful allotransplantation of the liver, 4 heart, 5 lung, 6 pancreas, 7 intestine, 8 multiple abdominal viscera, 9 and bone marrow. 10,11 Such milestones are never eroded from the landscape, but their appearance changes as the days wear on.…”

Interventional Techniques in the Management of Airway Complications Following Lung Transplantation

“…Over the next 20 years, only 40 more transplants were performed and only one of these patients survived as long as 10 months. 5,6 However, it was during these early years that many surgical techniques related to LTx were described and improved upon. 7 Among these critical advances included the crucial observation that shortening the donor bronchus improved airway healing because it became clear that postoperative bronchial ischemia played a major role in airway complications such as stenosis and bronchomalacia.…”

The Birth of Clinical Organ Transplantation

“…By the end of the decade, therapeutic regimens were available with which successful clinical transplantation of five kinds of organ allografts, as well as allogeneic bone marrow cells, were accomplished (Table 1). [12][13][14][15][16][17] In my individual contribution to the UCLA conference,18 I pointed out that almost all of the clinical transplantation milestones could be traced to two seminal discoveries that were turning points from which divergent management strategies evolved; one leading to bone marrow transplantation and the other to organ transplantation. The first discovery, made in the experimentallaboratory and eventually applied in the clinic, was that acquired tolerance to allografts could be induced.…”