The Southeast Asian xyleborine ambrosia beetle fauna is reviewed for the first time. Thirty-four genera and 315 species are reviewed, illustrated, and keyed to genera and species. Sixty-three new species are described: Amasa cycloxystersp. nov., Amasa galeodermasp. nov., Amasa gibbosasp. nov., Amasa linisp. nov., Amasa tropidacronsp. nov., Amasa youliisp. nov., Ambrosiophilus caliginestrissp. nov., Ambrosiophilus indicussp. nov., Ambrosiophilus lannaensissp. nov., Ambrosiophilus papilliferussp. nov., Ambrosiophilus wantaneeaesp. nov., Anisandrus achaetesp. nov., Anisandrus aucosp. nov., Anisandrus auratipilussp. nov., Anisandrus congruenssp. nov., Anisandrus cryphaloidessp. nov., Anisandrus feroniasp. nov., Anisandrus herasp. nov., Anisandrus paragogussp. nov., Anisandrus sinivalisp. nov., Anisandrus venustussp. nov., Anisandrus xuannusp. nov., Arixyleborus crassiorsp. nov., Arixyleborus phiaoacensissp. nov., Arixyleborus setosussp. nov., Arixyleborus silvanussp. nov., Arixyleborus sittichayaisp. nov., Arixyleborus titanussp. nov., Coptodryas amydrasp. nov., Coptodryas carinatasp. nov., Coptodryas inornatasp. nov., Cyclorhipidion amasoidessp. nov., Cyclorhipidion amputatumsp. nov., Cyclorhipidion denticaudasp. nov., Cyclorhipidion muticumsp. nov., Cyclorhipidion obesulumsp. nov., Cyclorhipidion petrosumsp. nov., Cyclorhipidion truncaudinumsp. nov., Cyclorhipidion xeniolumsp. nov., Euwallacea geminussp. nov., Euwallacea neptissp. nov., Euwallacea subalpinussp. nov., Euwallacea testudinatussp. nov., Heteroborips fastigatussp. nov., Heteroborips indicussp. nov., Microperus latesalebrinussp. nov., Microperus minaxsp. nov., Microperus sagmatussp. nov., Streptocranus petilussp. nov., Truncaudum bullatumsp. nov., Xyleborinus cuneatussp. nov., Xyleborinus disgregussp. nov., Xyleborinus echinopterussp. nov., Xyleborinus ephialtodessp. nov., Xyleborinus huifenyinaesp. nov., Xyleborinus jianghuansunisp. nov., Xyleborinus thaiphamisp. nov., Xyleborinus tritussp. nov., Xyleborus opacussp. nov., Xyleborus sunisaesp. nov., Xyleborus yunnanensissp. nov., Xylosandrus bellinsulanussp. nov., Xylosandrus spinifersp. nov.. Thirteen new combinations are given: Ambrosiophilus consimilis (Eggers) comb. nov., Anisandrus carinensis (Eggers) comb. nov., Anisandrus cristatus (Hagedorn) comb. nov., Anisandrus klapperichi (Schedl) comb. nov., Anisandrus percristatus (Eggers) comb. nov., Arixyleborus resecans (Eggers) comb. nov., Cyclorhipidion armiger (Schedl) comb. nov., Debus quadrispinus (Motschulsky) comb. nov., Heteroborips tristis (Eggers) comb. nov., Leptoxyleborus machili (Niisima) comb. nov., Microperus cruralis (Schedl) comb. nov., Planiculus shiva (Maiti & Saha) comb. nov., Xylosandrus formosae (Wood) comb. nov. Twenty-four new synonyms are proposed: Ambrosiophilus osumiensis (Murayama, 1934) (= Xyleborus nodulosus Eggers, 1941 syn. nov.); Ambrosiophilus subnepotulus (Eggers, 1930) (= Xyleborus cristatuloides Schedl, 1971 syn. nov.); Ambrosiophilus sulcatus (Eggers, 1930) (= Xyleborus sinensis Eggers, 1941 syn. nov.; = Xyleborus sulcatulus Eggers, 1939 syn. nov.); Anisandrus hirtus (Hagedorn, 1904) (= Xyleborus hirtipes Schedl, 1969 syn. nov.); Cnestus protensus (Eggers, 1930) (= Cnestus rostratus Schedl, 1977 syn. nov.); Cyclorhipidion bodoanum (Reitter, 1913) (= Xyleborus misatoensis Nobuchi, 1981 syn. nov.); Cyclorhipidion distinguendum (Eggers, 1930) (= Xyleborus fukiensis Eggers, 1941 syn. nov.; = Xyleborus ganshoensis Murayama, 1952 syn. nov.); Cyclorhipidion inarmatum (Eggers, 1923) (= Xyleborus vagans Schedl, 1977 syn. nov.); Debus quadrispinus (Motschulsky, 1863) (= Xyleborus fallax Eichhoff, 1878 syn. nov.); Euwallacea gravelyi (Wichmann, 1914) (= Xyleborus barbatomorphus Schedl, 1951 syn. nov.); Euwallacea perbrevis (Schedl, 1951) (= Xyleborus molestulus Wood, 1975 syn. nov.; Euwallacea semirudis (Blandford, 1896) (= Xyleborus neohybridus Schedl, 1942 syn. nov.); Euwallacea sibsagaricus (Eggers, 1930) (= Xyleborus tonkinensis Schedl, 1934 syn. nov.); Euwallacea velatus (Sampson, 1913) (= Xyleborus rudis Eggers, 1930 syn. nov.); Microperus kadoyamaensis (Murayama, 1934) (= Xyleborus pubipennis Schedl, 1974 syn. nov.; =Xyleborus denseseriatus Eggers, 1941 syn. nov.); Stictodex dimidiatus (Eggers, 1927) (=Xyleborus dorsosulcatus Beeson, 1930 syn. nov.); Webbia trigintispinata Sampson, 1922 (= Webbia mucronatus Eggers, 1927 syn. nov.); Xyleborinus artestriatus (Eichhoff, 1878) (= Xyelborus angustior [sic] Eggers, 1925 syn. nov.; = Xyleborus undatus Schedl, 1974 syn. nov.); Xyleborinus exiguus (Walker, 1859) (= Xyleborus diversus Schedl, 1954 syn. nov.); Xyleborus muticus Blandford, 1894 (= Xyleborus conditus Schedl, 1971 syn. nov.; = Xyleborus lignographus Schedl, 1953 syn. nov.). Seven species are removed from synonymy and reinstated as valid species: Anisandrus cristatus (Hagedorn, 1908), Cyclorhipidion tenuigraphum (Schedl, 1953), Diuncus ciliatoformis (Schedl, 1953), Euwallacea gravelyi (Wichmann, 1914), Euwallacea semirudis (Blandford, 1896), Microperus fulvulus (Schedl, 1942), Xyleborinus subspinosus (Eggers, 1930).