Ten simple rules for conducting umbrella reviews

Abstract

The current manuscript provides a practical guidance for conducting umbrella reviews in medical areas. Researchers, clinicians and policy makers might use the key points illustrated here to inform the planning, conduction and reporting of umbrella reviews in medicine.

Providing the most appropriate care to our individual patients

“…This fragmented approach does not support optimal clinical decision-making,12 and the need for a robust method to summarise evidence across several, indeed many, interventions has been increasingly recognised 13. Network meta-analysis has been developed to (1) synthesise evidence across a network of randomised trials, (2) allow the estimation of the relative effectiveness of several interventions and (3) produce ranked treatment options 14.…”

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