Ten‐year followup study of patients with <i>yersinia</i> arthritis

Leirisalo‐Repo, Marjatta; Suoranta, H

doi:10.1002/art.1780310410

Cited by 106 publications

(35 citation statements)

References 25 publications

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“…The frequency of HLA B27 in our patients (44%) compared with 27% and 30% in two unselected series indicates that in JCA HLA B27 is associated with a poor outcome. The same has been noticed in adult patients with Yersinia arthritis [23]. Because the HLA B27 antigen has been reported to be associated in Caucasians with several DR-locus alleles [24], the direct role of HLA B27 cannot be regarded as firmly established.…”

Section: Discussionmentioning

confidence: 76%

HLA B27: A prognostic factor in juvenile chronic arthritis

Savolainen¹,

Lehtimäki

Kautiainen³

et al. 1998

Clin Rheumatol

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This study was performed to assess the frequency of HLA B27 in patients with juvenile chronic arthritis (JCA) of varying severity and outcome by studying three patient categories: those in whom cytostatic treatment with azathioprine had been started, those with secondary amyloidosis, and those with arthroplasty of the knee or hip joints. In the first category the frequency of the HLA B27 allele was compared between those who had attained remission and those who had not. In the second and third categories the rate at which amyloidosis developed and the timing for the need of arthroplasty, were compared for HLA B27-positive and -negative patients. A control group consisted of 37 patients with uncomplicated seronegative polyarthritis. Ten of the 37 patients in the control group (27%) were HLA B27 positive as opposed to 84 out of 190 (44%) in the three study groups. Of the 101 patients treated with azathioprine, two out of 15 in remission were HLA B27 positive, whereas as many as 41 out of 86 with still active disease were HLA B27 positive (p = 0.013). Of the secondary amyloidosis patients, 29 out of 51 carried HLA B27. The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients (p = 0.038). Of the arthroplasty patients, 39 out of 91 carried HLA B27. The HLA B27-positive patients underwent arthroplasty on average 2.9 (median 3.5) years earlier than the HLA B27-negative patients (p = 0.050). We conclude that HLA B27-positive cases are accumulated among the most severe cases of JCA.

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Section: Discussionmentioning

confidence: 76%

HLA B27: A prognostic factor in juvenile chronic arthritis

Savolainen¹,

Lehtimäki

Kautiainen³

et al. 1998

Clin Rheumatol

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“…Although bacterial infection such as Chlamydia could cause chronic arthritis [40], it is still premature to conclude that bacterial infection can cause AS [41]. Conversely, evidence suggests that AS disease activity became worse, following the different bacterial infections such as Salmonella, Yersinia, Campylobacter and Chlamydia [42][43][44][45][46]. Although molecular mimicry between the bacterial components and self-peptides was considered to play a role [47], our results may provide an alternative explanation, that the bacterial LPS could suppress IFN-g production in activated normal T cells.…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis

Lai

Chen

et al. 2013

Clinical and Experimental Immunology

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Summary Ankylosing spondylitis (AS) is a chronic inflammatory disorder characterized by dysregulated T cells. We hypothesized that the aberrant expression of microRNAs (miRNAs) in AS T cells involved in (TLR-4), a target of let-7i, in T cells from AS patients were decreased. In addition, the mRNA expression of interferon (IFN)-g was elevated in AS T cells. Lipopolysaccharide (LPS), a TLR-4 agonist, inhibited IFN-g secretion by anti-CD3+ anti-CD28 antibodiesstimulated normal T cells but not AS T cells. In the transfection studies, we found the increased expression of let-7i enhanced IFN-g production by anti-CD3 + anti-CD28 + lipopolysaccharide (LPS)-stimulated normal T cells. In contrast, the decreased expression of let-7i suppressed IFN-g production by anti-CD3 + anti-CD28 + LPS-stimulated AS T cells. In conclusion, we found that miR-16, miR-221 and let-7i were over-expressed in AS T cells, but only miR-221 and let-7i were associated with BASRI of lumbar spine. In the functional studies, the increased let-7i expression facilitated the T helper type 1 (IFN-g) immune response in T cells.

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“…Usually arthritis is self-limiting, but a subset of patients develop chronic arthritis (15). Originally, reactive arthritis was supposed to occur in the absence of bacteria from the joint.…”

mentioning

confidence: 99%

Infection of Synovial Fibroblasts in Culture by Yersinia enterocolitica and Salmonella enterica Serovar Enteritidis: Ultrastructural Investigation with Respect to the Pathogenesis of Reactive Arthritis

et al. 2001

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Synovial fibroblasts were infected with Yersinia enterocolitica or Salmonella enterica serovar Enteritidis and analyzed by electron microscopy and fluorescence in situ hybridization. Intracellular bacterial replication was followed by degradation leading to "ghosts" possessing lipopolysaccharides but not DNA. However, single bacteria survived for more than 2 weeks. Therefore, transient intra-articular infection might be the missing link between initial intestinal infection and late synovial inflammation in the pathogenesis of reactive arthritis.

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Ten‐year followup study of patients with yersinia arthritis

Cited by 106 publications

References 25 publications

HLA B27: A prognostic factor in juvenile chronic arthritis

HLA B27: A prognostic factor in juvenile chronic arthritis

Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis

Infection of Synovial Fibroblasts in Culture by Yersinia enterocolitica and Salmonella enterica Serovar Enteritidis: Ultrastructural Investigation with Respect to the Pathogenesis of Reactive Arthritis

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