Ten-year graft survival of deceased-donor kidney transplantation: a single-center experience

Abstract

Background: Kidney transplantation is the treatment of choice for end-stage renal disease that restores the patients' quality of life and reduces the morbidity and mortality rates induced by renal failure and its complications. However, after transplantation the organ and patient survival rates are important issues of interest in many centers worldwide. Subjects and methods: This is a historical cohort study planned to determine the organ survival rate after kidney transplantation from deceased donor during a period of 10 years (March 1999-March 2009 in Shiraz Transplant Center, Namazi Hospital, Shiraz, Iran. We tried to clarify the probable contributory risk factors implicating in graft loss. Kaplan-Meier method was used to determine the survival rate. Log-rank test was used to compare survival curves, and Cox regression model to define the hazard ratio and for modeling of factors implicating in survival rate. Results: Mean follow-up period was 37.54 ± 28.6 months. Allograft survival rates at 1, 3, 5, and 9 years after kidney transplantation from deceased donor (calculated by Kaplan-Meier method) was found to be 93.7, 89.1, 82.1, and 80.1%, respectively. Duration of dialysis before operation and creatinine level at discharge were showed to be the most important factors influencing survival rate of renal allograft. Conclusion: Overall long-term graft survival in our cohort is satisfactory and comparable with reports from large centers in the world. Duration of dialysis before operation and creatinine level at discharge are the only independent factors that could correlate with long-term graft survival in our cohort.

QT Intervals in Patients Receiving a Renal Transplant

“…1 However, transplant recipients die prematurely and increasingly because of cardiovascular disease. 2,3 A cardiovascular event in a transplant recipient may be the result of a pretransplant disease process, a direct effect of immunosuppressant medications, or the result of exposure to a several traditional and nontraditional risk factors.…”

One-year survival rate of renal transplant: factors influencing the outcome

“…1 Although there are 3 different resources for organ attainment, including live related, live unrelated, and deceased donors, organ shortage is still the biggest obstacle restricting transplantation. 9 In Iran, the rate of renal transplantation approximates 24 grafts per 1 million populations per year and almost half of ESRD patients are still on hemodialysis. 3,9 Living unrelated donors are the largest (85%) transplantation source.…”

“…9 In Iran, the rate of renal transplantation approximates 24 grafts per 1 million populations per year and almost half of ESRD patients are still on hemodialysis. 3,9 Living unrelated donors are the largest (85%) transplantation source. 10 Cadaveric donation is lower than expected in Iran due to cultural, legal, and medical issues.…”

Factors Affecting Allograft and Patient Survival in Deceased Donor Kidney Transplantation: A Single Center Experience in Turkey

“…We have demonstrated the relationship with high Scr value at discharge and that early surgical complications are associated with allograft failure. It has been shown in previous studies that Scr value at discharge (2 mg/dL or less) has an inverse relationship with graft survival (11)(12)(13)(14).…”

“…The overall incidence of arterial thrombosis ranges between 0.4-3.0% and venous thrombosis between 0.4-3.4% in DDKTx patients (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Deceased donor is a significant risk factor for developing renal allograft thrombosis along with donor age <6 or >60 years, recipient age <5-6 or >50 years, hemodynamic instability, peritoneal dialysis, recipient vessel atherosclerosis, diabetic nephropathy, a history of thrombosis, and DGF (24)(25)(26).…”