Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage

Lindqvist, Elisabet

doi:10.1136/ard.61.12.1055

Cited by 149 publications

(101 citation statements)

References 22 publications

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“…In our study, the HAQ score decreased after the initiation of DMARD treatment and remained low throughout the entire followup period in both study groups. We emphasize that after 11 years of RA, half of our patients had no disability according to the HAQ score, a finding that is in notable contrast with previously described cohorts (22,24).…”

Section: Discussioncontrasting

confidence: 99%

“…There are few truly long-term (Ն10 years) followup studies on early RA that include clinical outcomes. Most of these studies have neither a definite nor an active treatment protocol, and the results can be considered to represent the course of conservatively treated RA (20)(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…Other studies of early RA with long-term followup but with more conservative treatment strategies have shown a constantly deteriorating course of the HAQ scores (22,24). However, studies with shorter followup periods and active strategies using a single DMARD (25), combinations of conventional DMARDs (3,9), or biologic agents (6,7) have actually shown functional improvement.…”

Section: Discussionmentioning

confidence: 99%

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The good initial response to therapy with a combination of traditional disease‐modifying antirheumatic drugs is sustained over time: The eleven‐year results of the Finnish rheumatoid arthritis combination therapy trial

Rantalaiho

Korpela

Hannonen

et al. 2009

Arthritis & Rheumatism

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The good initial response to therapy with a combination of traditional disease‐modifying antirheumatic drugs is sustained over time: The eleven‐year results of the Finnish rheumatoid arthritis combination therapy trial

Rantalaiho

Korpela

Hannonen

et al. 2009

Arthritis & Rheumatism

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“…However, early in the disease course, the inflammatory process leads to a multitude of functional limitations (1)(2)(3)(4)(5). Several studies have also shown that RA is associated with a shortened life span, mainly due to coronary vascular disease (6 -8).…”

Section: Introductionmentioning

confidence: 99%

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

Thyberg¹,

Hass²,

Nordenskiöld³

et al. 2005

Arthritis & Rheumatism

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Objective. To evaluate activity limitations 3 years after diagnosis of early rheumatoid arthritis (RA) in relation to grip force and sex. Methods. A total of 217 patients, 153 women and 64 men, with recent-onset RA were included. Activity limitations were reported using the Health Assessment Questionnaire (HAQ) and the Evaluation of Daily Activities Questionnaire (EDAQ). The relationships between activity limitations versus grip force (measured by the Grippit), walking speed, functional impairment, grip ability, pain, plasma C-reactive protein, the 28-joint disease activity score and its components, the physician's global assessment of disease activity, and sex were analyzed by partial least squares (PLS). Results. Women had significantly lower grip force and more activity limitations (HAQ and EDAQ) than men. The PLS analyses demonstrated that grip force was the strongest regressor of activity limitation, closely followed by walking speed. However, within subgroups based on grip force (group 1 ‫؍‬ grip force <114 N, group 2 ‫؍‬ 116 -206 N, group 3 ‫؍‬ 214 -321 N, group 4 ‫؍‬ grip force >328 N) and including sexes, women and men had corresponding degrees of activity limitation as reported by the HAQ and EDAQ. Conclusion. Our results indicate that the more pronounced activity limitations seen in women with RA, as compared with men, may be explained by lower grip force rather than sex.

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“…Damage seen on X-rays is largely irreversible and represents a cumulative process. It has been shown that radiographic progression is associated with loss of physical function [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

The presence of rheumatoid nodules at early rheumatoid arthritis diagnosis is a sign of extra-articular disease and predicts radiographic progression of joint destruction over 5 years

Nyhall-Wahlin

Turesson²,

Jacobsson³

et al. 2010

Scandinavian Journal of Rheumatology

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Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage

Cited by 149 publications

References 22 publications

The good initial response to therapy with a combination of traditional disease‐modifying antirheumatic drugs is sustained over time: The eleven‐year results of the Finnish rheumatoid arthritis combination therapy trial

The good initial response to therapy with a combination of traditional disease‐modifying antirheumatic drugs is sustained over time: The eleven‐year results of the Finnish rheumatoid arthritis combination therapy trial

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

The presence of rheumatoid nodules at early rheumatoid arthritis diagnosis is a sign of extra-articular disease and predicts radiographic progression of joint destruction over 5 years

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