Nowadays, a challenge in Climate Science is the seasonal forecast and knowledge of the model’s performance in different regions. The challenge in South America reflects its huge territory; some models present a good performance, and others do not. Nevertheless, reliable seasonal climate forecasts can benefit numerous decision-making processes related to agriculture, energy generation, and extreme events mitigation. Thus, given the few works assessing the ECMWF-SEAS5 performance in South America, this study investigated the quality of its seasonal temperature and precipitation predictions over the continent. For this purpose, predictions from all members of the hindcasts (1993–2016) and forecasts (2017–2021) ensemble were used, considering the four yearly seasons. The analyses included seasonal mean fields, bias correction, anomaly correlations, statistical indicators, and seasonality index. The best system’s performance occurred in regions strongly influenced by teleconnection effects, such as northern South America and northeastern Brazil, in which ECMWF-SEAS5 even reproduced the extreme precipitation anomalies that happened in recent decades. Moreover, the system indicated a moderate capability of seasonal predictions in medium and low predictability regions. In summary, the results show that ECMWF-SEAS5 climate forecasts are potentially helpful and should be considered to plan various strategic activities better.