Ten years of clinical experience with adult meningitis at an urban academic medical center

Pizon, Anthony F.; Bonner, Matthew; Wang, Henry E.; Kaplan, Richard M

doi:10.1016/j.jemermed.2005.07.010

Cited by 35 publications

(20 citation statements)

References 8 publications

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“…According to a study by Pizon et al13 CSF staining and culture provide the diagnostic basis in 60%–90% of patients with meningitis. Previous studies have shown that prophylactic use of antibiotics can effectively reduce the incidence of PCNSI 14,15.…”

Section: Discussionmentioning

confidence: 99%

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Zhou

Zhang

2014

NDT

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AimOur aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of treatment.MethodsThis retrospective study assessed 283 patients with postoperative bacterial meningitis in the Neurosurgery Department of Beijing Tiantan Hospital, Beijing, People’s Republic of China, between January and December 2012. Patients’ clinical data were reviewed, and multivariate logistic regression analysis was used to identify the factors associated with a prolonged treatment course.ResultsThe mortality rate was 0.4% in these patients, of whom 12.4% were found with pathogens in the cerebrospinal fluid. Among the three most common pathogens detected were methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa. The mean treatment course was 13.5±2.1 days. Interestingly, the treatment duration for postoperative meningitis was significantly longer in patients with intracranial malignant tumors than in those with benign lesions. Single-factor analysis showed that male sex (P=0.042) and malignant (rather than benign) lesions (P<0.001) were significantly associated with prolonged treatment duration. Multivariate analysis further confirmed that malignant intracranial lesions represented an independent risk factor for prolonged treatment duration (odds ratio: 2.5962; 95% confidence interval: 1.1092–6.6134).ConclusionThe nature of the intracranial lesion is an independent risk factor for the duration of treatment in postoperative meningitis after neurosurgery.

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Section: Discussionmentioning

confidence: 99%

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Zhou

Zhang

2014

NDT

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“…S. aureus is an uncommon cause of bacterial meningitis, accounting for 4.9 to 6.4% of cases (779)(780)(781)(782)(783)(784). S. aureus meningitis may either arise by hematogenous spread from a non-CNS focus of infection or be secondary to neurosurgical intervention (785,786).…”

Section: Meningitismentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…Classic textbook signs and symptoms include fever, nuchal rigidity, altered mental status (such as lethargy), and headache. Patients who are very young, elderly, or immunocompromised may present atypically and can have a paucity of these symptoms; however, studies consistently report that the vast majority will have at least one traditional finding [4,8]. Other classic associations include Brudzinski's and Kernig's signs.…”

Section: Signs and Symptomsmentioning

confidence: 99%

Rapidly Fatal Infections

Hans

Kelly

Wilhelmson

et al. 2008

Emergency Medicine Clinics of North America

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Emergency physicians are trained to separate "sick" from "not sick" patients during their training. Nevertheless, every emergency physician will face situations in which early intervention is critical to their patient's outcome. Infectious diseases are responsible for many of these potentially poor outcomes. This article discusses early identification and treatment for several rapidly fatal infections, including two newly identified travel-related illnesses.

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Ten years of clinical experience with adult meningitis at an urban academic medical center

Cited by 35 publications

References 8 publications

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Rapidly Fatal Infections

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Ten years of clinical experience with adult meningitis at an urban academic medical center

Cited by 35 publications

References 8 publications

Intracranial malignant lesions correlate with the requirement for a long treatment course in&nbsp;postoperative central nervous system infection

Intracranial malignant lesions correlate with the requirement for a long treatment course in&nbsp;postoperative central nervous system infection

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Rapidly Fatal Infections

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Product

Resources

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Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection

Intracranial malignant lesions correlate with the requirement for a long treatment course in postoperative central nervous system infection