Ten years of experience with endometrial cancer treatment in a single Brazilian institution: Patient characteristics and outcomes

Abstract

Few reports have described the clinical and prognostic characteristics of endometrial cancer, which is increasing worldwide, in large patient series in Brazil. Our objective was to analyze the clinicopathological characteristics, prognostic factors, and outcomes of patients with endometrial cancer treated and followed at a tertiary Brazilian institution over a 10-year period.This retrospective study included 703 patients diagnosed with endometrial cancer who were treated at a public academic tertiary hospital between 2008 and 2018. The following parameters were analyzed: age at diagnosis, race, body mass index, serum CA125 level before treatment; histological type and grade, and surgical stage. Outcomes were reported relative to histological type, surgical staging, serum CA125, lymph-vascular space involvement (LVSI), and lymph-node metastasis. The median patient age at diagnosis was 63 (range, 27-93) years (6.4% were <50 years). Minimally invasive surgeries were performed in 523 patients (74.4%). Regarding histological grade, 468 patients (66.5%) had low-grade endometrioid histology and 449 patients (63.9%) had stage I tumors. Tumors exceeded 2.0 cm in 601 patients (85.5%). Lymphadenectomy was performed in 551 cases (78.4%). LVSI was present in 208 of the patients' tumors (29.5%). Ninety-three patients (13.2%) had recurrent tumors and 97 (13.7%) died from their malignant disease. The robust prognostic value of FIGO stage and

Risk Factors for Surgical Treatment of Endometrial Cancer Using Traditional and Laparoscopic Methods

“…The duration of hospitalization in patients treated with laparotomy was significantly longer compared with laparoscopy (11.3 ± 3.1 days vs. 6.5 ± 1.7 days, p < 0.001). These durations appear longer than in some other centers [ 13 , 14 ]. The longer hospitalization time in this study can be explained by local specificity of outpatient care, which is ineffective both in the period of preoperative diagnostics and in postoperative supervision.…”

Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer

“…High rates of adjuvant therapy have been reported in retrospective series of EC patients [2,8,12] in contrast with prospective data from clinical trials of surgically treated patients. [18,19] In this current study, the use of complementary treatment was applied in 40.1% of patients, which contrasts with a rate of 67.5% in our previous report involving patients from the public health system.…”

Expression profile of epithelial-mesenchymal transition-related genes as a prognostic biomarker of endometrial cancer

“…Endometrial cancer represents the sixth commonest malignancy affecting women around the world, with 382,096 new diagnoses in 2018 [1]. The majority of endometrial cancer cases can be diagnosed and treated early, e.g.…”

“…In this case, median survival is only 12 months [3,4]. Overall, 89,929 women died from endometrial cancer in 2018 [1]. Therefore, it is crucial to identify tools for early detection of endometrial cancer.…”