Ten Years of Growth Hormone (GH) Replacement Normalizes Muscle Strength in GH-Deficient Adults

Götherström, Galina; Elbornsson, Mariam; Sunnerhagen, Katharina Stibrant; Bengtsson, Bengt‐Åke; Johannsson, Gudmundur; Svensson, Johan

doi:10.1210/jc.2008-1538

Cited by 69 publications

(66 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with the lipolytic and anabolic effects of GH observed in previous studies (4,10,23,24), demonstrating that a moderate dose of GH can induce a sustained improvement in body composition in elderly GHD adults. GH replacement, as previously shown (10,25), had a more marked effect on isometric knee flexor strength than on isokinetic knee flexor strength, possibly as a consequence of more reduced isometric strength in untreated GHD adults (9,26). This allows to assume that increased muscle strength during GH replacement is not only due to increased muscle mass (27)(28)(29).…”

Section: Discussionsupporting

confidence: 92%

“…In a previous study, we observed a more marked response in muscle performance following the 10-year GH replacement in patients below 50 years of age compared to patients older than 50 years (10). In the present study, we therefore investigated whether the 10-year GH replacement could affect muscle strength in elderly adults with GHD above 60 years of age.…”

Section: Discussionmentioning

confidence: 83%

“…However, absolute values of muscle strength returned towards baseline values between 5 and 10 years of GH replacement in GHD adults of various ages in one study (10).…”

Section: Introductionmentioning

confidence: 90%

“…The results of several studies suggest that the reduced muscle strength in young GHD adults can be reversed by GH replacement (3,(7)(8)(9)(10). However, absolute values of muscle strength returned towards baseline values between 5 and 10 years of GH replacement in GHD adults of various ages in one study (10).…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Götherström¹,

Elbornsson²,

Sunnerhagen³

et al. 2010

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Context: Only few studies have investigated the effects of GH replacement on muscle strength in elderly patients with GH deficiency (GHD). Objective, design, and patients: In this prospective open-labeled study, the effects of 10 years of GH replacement on muscle strength and neuromuscular function were followed in 24 elderly GHD adults (mean age of 65.2 years; range 61-74 years). Muscle strength was compared with reference values obtained from the background population. Results: The mean initial GH dose of 0.72 mg/day was lowered to 0.37 mg/day. The mean IGF1 SDS increased from K1.10 at baseline to 1.17 at study end. GH replacement induced a sustained increase in lean body mass and a transient increase in isometric knee flexor strength. Isometric knee extensor strength was reduced after 10 years. However, after correction for age and gender, using observed/predicted value ratios, there was sustained and even progressive increase in most variables reflecting muscle strength. Measurements of neuromuscular function showed unchanged voluntary motor unit activation after 10 years. Conclusions: Ten years of GH replacement therapy in elderly GHD adults resulted in a transient increase in isometric knee flexor strength, and provided protection from most of the normal age-related decline in muscle performance and neuromuscular function.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 83%

“…However, absolute values of muscle strength returned towards baseline values between 5 and 10 years of GH replacement in GHD adults of various ages in one study (10).…”

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Götherström¹,

Elbornsson²,

Sunnerhagen³

et al. 2010

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Growth hormone (GH) therapy has yielded favorable results for childhood growth disorders and adult growth hormone deficiency (GHD) [1,2]. However, the potential for the application of GH recombinant products in patients with growth hormone deficiency (GHD) is limited by the high cost, attendant risks, and inconvenience of the necessary exogenous s.c. injections.…”

Section: Introductionmentioning

confidence: 99%

A microarray gene analysis of peripheral whole blood in normal adult male rats after long-term GH gene therapy

Qin

Tian

2010

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

The main aims of this study were to determine the effects of GH gene abuse/misuse in normal animals and to discover genes that could be used as candidate biomarkers for the detection of GH gene therapy abuse/misuse in humans. We determined the global gene expression profile of peripheral whole blood from normal adult male rats after long-term GH gene therapy using CapitalBio 27 K Rat Genome Oligo Arrays. Sixty one genes were found to be differentially expressed in GH gene-treated rats 24 weeks after receiving GH gene therapy, at a two-fold higher or lower level compared to the empty vector group (p < 0.05). These genes were mainly associated with angiogenesis, oncogenesis, apoptosis, immune networks, signaling pathways, general metabolism, type I diabetes mellitus, carbon fixation, cell adhesion molecules, and cytokine-cytokine receptor interaction. The results imply that exogenous GH gene expression in normal subjects is likely to induce cellular changes in the metabolism, signal pathways and immunity. A real-time qRT-PCR analysis of a selection of the genes confirmed the microarray data. Eight differently expressed genes were selected as candidate biomarkers from among these 61 genes. These 8 showed five-fold higher or lower expression levels after the GH gene transduction (p < 0.05). They were then validated in real-time PCR experiments using 15 single-treated blood samples and 10 control blood samples. In summary, we detected the gene expression profiles of rat peripheral whole blood after long-term GH gene therapy and screened eight genes as candidate biomarkers based on the microarray data. This will contribute to an increased mechanistic understanding of the effects of chronic GH gene therapy abuse/misuse in normal subjects.

show abstract

Adult Growth Hormone Deficiency

Vaughan

Riley

Blevins

2013

Pituitary Disorders

View full text Add to dashboard Cite

Ten Years of Growth Hormone (GH) Replacement Normalizes Muscle Strength in GH-Deficient Adults

Abstract: Ten years of GH replacement therapy increased muscle strength during the first half of the study and thereafter partly protected against the normal age-related decline in muscle strength and neuromuscular function, resulting in approximately normalized muscle strength after 10 yr.

Cited by 69 publications

References 34 publications

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

Muscle strength in elderly adults with GH deficiency after 10 years of GH replacement

A microarray gene analysis of peripheral whole blood in normal adult male rats after long-term GH gene therapy

Adult Growth Hormone Deficiency

Contact Info

Product

Resources

About