Tenascin-C deficiency attenuates abdominal aortic aneurysm formation

Podemos adotar a dosagem sérica da Tenascina-C na avaliação prognóstica do aneurisma e dissecção da aorta?

“… 15 The value observed in the control KO group was 0.92±0.08 and the value in the control WT group was 0.96±0.22. 15 They investigated the relationship between TN-C deficiency and its capacity to attenuate AAA formation. 15 They conducted laparotomies on male mice and then, in some of the mice from the KO group, in which the genes responsible for transcription of TN-C had been knocked out, induced AAA by periaortic administration of calcium chloride 0.5 M for 15 minutes, while in some of the mice in the WT group they conducted the same procedure, but incubated the artery in saline solution.…”

“…Schaefer et al reported figures valid for mice: in a group of knockout mice (KO), a mean level of 1.39±0.25 μ/mL was observed and in a group of wildtype mice (WT) the mean level was 1.67±0.22 μg/mL. 15 The value observed in the control KO group was 0.92±0.08 and the value in the control WT group was 0.96±0.22. 15 They investigated the relationship between TN-C deficiency and its capacity to attenuate AAA formation.…”

“… 15 They investigated the relationship between TN-C deficiency and its capacity to attenuate AAA formation. 15 They conducted laparotomies on male mice and then, in some of the mice from the KO group, in which the genes responsible for transcription of TN-C had been knocked out, induced AAA by periaortic administration of calcium chloride 0.5 M for 15 minutes, while in some of the mice in the WT group they conducted the same procedure, but incubated the artery in saline solution. The authors measured the diameter of the abdominal aorta before aneurysm induction and three and ten weeks after aortic transplant, calculating the proportions between the measurements.…”

“…The authors measured the diameter of the abdominal aorta before aneurysm induction and three and ten weeks after aortic transplant, calculating the proportions between the measurements. 15 …”

“…Based on these results, the authors associated TN-C deficiency with a lower probability of AAA formation. 15 …”