Tenascin Staining Positivity and the Survival of Patients with Invasive Breast Carcinoma

Shoji, Tetsuji; Kamiya, Tomoo; Tsubura, Airo; Hamada, Y.; Hatano, Takehiko; Hioki, Koshiro; Morii, Sotokichi

doi:10.1006/jsre.1993.1143

Cited by 36 publications

(21 citation statements)

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“…This finding has been described by others in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992Riedel et al, , 1995Sakai et al, 1993;Hauptmann et al, 1995) and in several other tumour types (Natali and Zardi, 1989;Ibrahim et al, 1993;Moch et al, 1993;Shoji et al, 1993;Ikeda et al, 1995;Ilunga and Iriyama, 1995;Yoshida et al, 1995). Like Sugawara et al (1991), we also found two different staining patterns.…”

Section: Discussionsupporting

confidence: 91%

“…Several reports have shown an up-regulation of tenascin in various tumour stroma, such as breast (Moch et al, 1993;Shoji et al, 1993;Yoshida et al, 1995), lung (Natali and Zardi, 1989), prostatic (Ibrahim et al, 1993) and gastric carcinomas (Ikeda et al, 1995;Ilunga and Iriyama, 1995). Studies of this putative marker of the tumour matrix are also of considerable interest in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992;Sakai et al, 1993;Hauptmann et al, 1995;Riedel et al, 1995) because of the potential involvement of tenascin (or tenascin-like proteins) in cell adhesion and invasion during the metastatic process.…”

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confidence: 99%

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Stromal tenascin distribution as a prognostic marker in colorectal cancer

Kressner

Lindmark²,

Tomasini-Johansson³

et al. 1997

Br J Cancer

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Summary A total of 169 colorectal adenocarcinomas, obtained from patients with a median follow-up of 6.5 years, were studied with immunohistochemical staining on cryosections using a monoclonal anti-tenascin antibody to evaluate the possible association between the staining patterns and tumour stage, tumour differentiation and survival. We found two different staining patterns in the tumour stroma -a diffuse stromal fibrillar staining in 92 out of 169 (54%) tumours and a subglandular staining in the remaining 77 tumours. When the entire group of patients (P < 0.01) and the group of potentially cured patients (P < 0.03) were analysed univariately, it was found that diffuse stromal fibrillar staining was associated with a shorter survival time than subglandular staining. In a multivariate analysis, the Dukes' stage and age were independent prognostic factors, whereas the tenascin expression did not retain a clear independent relationship to survival (P = 0.06).Hence, it appears that the tumour expression of tenascin may be a potential prognostic marker in colorectal cancer, in so far as a diffuse stromal fibrillar staining pattern seems to indicate an increased risk of poor outcome. However, after adjustment for age and Dukes' stage, the additional prognostic value of tenascin remains to be established in further analyses.Keywords: tenascin; colorectal cancer; tumour stage; tumour differentiation; survival; immunohistochemistry Tenascin is a large hexameric extracellular matrix protein that is present during embryonic development but essentially absent in normal adult tissues (Schenk and Chiquet-Ehrismann, 1994) and is expressed only at low levels or in a very restricted distribution. Several tenascin isoforms have been described . Tenascin has been suggested to be of importance in the normal healing process and in tumours, in which its role is presumed to be connected with cell adhesion and detachment, cell growth, cell migration and angiogenesis (Mackie et al, 1988;Ekblom and Aufterheide, 1989;Erickson and Bourdon, 1989; ChiquetEhrismann, 1993;Hahn et al, 1995; Joshi et al, 1995). It has been proposed that, although tenascin has no cell adhesion activity, it does affect the cell shape and, thus, may inhibit cell attachment to other extracellular proteins, including fibronectin (Mackie, 1994). It is also thought that tenascin plays a role in coordinating the provisional extracellular matrix surrounding the cancer tissue (Sakakura and Kusakabe, 1994).Several reports have shown an up-regulation of tenascin in various tumour stroma, such as breast (Moch et al, 1993;Shoji et al, 1993;Yoshida et al, 1995), lung (Natali and Zardi, 1989), prostatic (Ibrahim et al, 1993) and gastric carcinomas (Ikeda et al, 1995;Ilunga and Iriyama, 1995). Studies of this putative marker of the tumour matrix are also of considerable interest in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992;Sakai et al, 1993;Hauptmann et al, 1995;Riedel et al, 1995) because of the potential involvement of tenascin (or tenascin-like proteins) i...

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Kressner

Lindmark²,

Tomasini-Johansson³

et al. 1997

Br J Cancer

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“…is strongly expressed in various types of cancers such as that of the breast, lung, stomach, liver, pancreas, colorectum, kidney, bladder and prostate (7)(8)(9)(10)(11)(12)(13)(14). The prognostic significance of tenascin-C expression remains controversial.…”

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confidence: 99%

“…The prognostic significance of tenascin-C expression remains controversial. Earlier studies on tenascin-C expression in colorectal and breast cancers showed that a positive stromal expression is associated with a favorable prognosis (11,14). However, Jahkola et al demonstrated that the stromal tenascin-C expression at the invasion border of breast cancer is a predictor of local and distant recurrences (15).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Prognostic significance of tenascin-C expression in clear cell renal cell carcinoma

Ohno

Izumi²,

Yoshioka³

et al. 1994

Oncol Rep

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Abstract. Tenascin-C is an extracellular matrix protein that plays an important role in cell proliferation, migration and tumor invasion in various types of cancer. However, few reports exist on tenascin-C expression in renal cell carcinoma (RCC). This study aimed to assess the prognostic significance of tenascin-C in clear cell RCC. Using immunohistochemistry, 137 formalin-fixed, paraffin-embedded tissue sections obtained from patients with clear cell RCC were examined for tenascin-C expression. Tenascin-C expression was observed in 55 (40.1%) of the 137 clear cell RCC sections. Tumor cells displayed membranous and/or cytoplasmic staining for tenascin-C. Tenascin-C expression was more prominent near the pseudocapsule of the tumor and around the tumor vessels. Tenascin-C expression was significantly associated with a higher stage (P=0.0065) and higher nuclear grade (P=0.0001). However, there was no correlation between the tenascin-C expression and venous involvement. The cancer-specific survival rate in patients with a tenascin-C-positive primary tumor was significantly lower than that in those with a tenascin-C-negative primary tumor in univariate analysis (P=0.0017). However, tenascin-C expression did not exhibit a significant value for cancer-related death in the Cox regression analysis. In patients with stage 1-3 disease, the 5-year metastasis-free rate in patients with the tenascin-C-positive primary tumor was significantly lower than that in those with the tenascin-C-negative primary tumor (67.8 vs. 88.5%, respectively; P=0.0038). The Cox regression analysis showed that tenascin-C expression is a significant predictor of metastasis (P=0.0345). The tenascin-C expression was strongly related to the stage, nuclear grade and 5-year metastasis-free rate. Therefore, tenascin-C expression may be a possible marker for the metastatic potential of clear cell RCC.

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“…Stromal tenascin-C expression has been associated with a better prognosis in cervical, colonic and breast cancer [11, 14, 15, 16]. In normal gastric tissue tenascin-C is expressed in the muscularis mucosae, muscularis propria and vessel walls, but not in normal gastric mucosa or submucosal connective tissue [17].…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C Expression Correlates with Prognosis in Gastric Cancer

Wiksten¹,

Lundin²,

Nordling

et al. 2003

Oncology

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Objectives: Tenascin-C is a hexameric extracellular matrix glycoprotein that is expressed during embryonic development and re-expressed in proliferative processes such as wound healing and tumorigenesis. Stromal tenascin-C may block tumor invasion and thus have a significant influence on tumor spread and prognosis. Methods: In the present study, tissue expression of stromal tenascin-C was studied by immunohistochemistry in a series of 314 patients with gastric cancer. Results: Strong tenascin-C positivity was seen in the stroma of the tumor in 122 (39%) cases. There was a correlation between strong tenascin-C expression and low stage (p = 0.002), superficial tumor penetration (p = 0.02), location of tumor at the distal third of the stomach (p = 0.03), and potentially curative surgery (p = 0.008). No significant correlation was found between tenascin-C positivity and nodal status, distant metastases, age, Laurén classification, gender, tumor size, or Borrmann classification. The cumulative 5-year survival in patients with strong tenascin-C expression was 42% compared to 26% in those with negative-to-moderate expression (p = 0.0053). In multivariate survival analysis stratified for estimated cure of surgery, stage of disease was the only independent prognostic factor. Conclusion: In conclusion, tenascin-C expression seems to correlate with cancer related survival in patients with gastric cancer, but may not add significant prognostic information to that provided by TNM stage.

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Tenascin Staining Positivity and the Survival of Patients with Invasive Breast Carcinoma

Cited by 36 publications

References 0 publications

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Prognostic significance of tenascin-C expression in clear cell renal cell carcinoma

Tenascin-C Expression Correlates with Prognosis in Gastric Cancer

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