Tendência temporal e perfil epidemiológico dos acidentes por animais peçonhentos no Brasil, 2007-2019

Souza, Tiago Cruz de; Farias, Beatrice Émeli Silva; Bernarde, Paulo Sérgio; Neto, Francisco Chiaravalloti; Frade, Djair Durand Ramalho; Brilhante, Andréia Fernandes; Melchior, Leonardo Augusto Kohara

doi:10.1590/s2237-96222022000300009

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…These results are in line with those of other research carried out in the southern region of Brazil for the period 2019-2021. 5 , 6 , 27 The first notifications corresponded to the Sertão region of the state of Pernambuco, followed by occurrences in municipalities closer to the coast, suggesting geographic displacement of cases. Rural and urban areas had similar notifications in numbers, unlike the cases cited in the Ministry of Health manual for the years 2001-2019, for which the urban area was the main place of occurrence, perhaps due to the greater demographic density in rural areas in northeast Brazil when compared to rural areas the southern region of the country.…”

Section: Discussionmentioning

confidence: 99%

“…2 , 3 , 25 As the Loxosceles spider usually inhabits domestic spaces, almost all accidents occurred in households, the expected habitat of these spiders, according to findings from other research carried out in southern Brazil for the period 2001-2019. 2 , 3 , 5 , 28…”

Section: Discussionmentioning

confidence: 99%

“…Spiders are one of the groups of venomous species that most cause poisoning in Brazil, with great variation in frequency between the country’s five macro-regions and time of year. 1 - 5 Brown spiders are arachnids comprising different species of the genus Loxosceles that can cause spider bite injuries. 6 , 7 In the Northeast region of Brazil, especially in the state of Pernambuco, an increase in notifications of loxoscelism cases on the Brazilian System for Recording Poison Information and Care Center Poisoning Data (DATATOX) was seen between 2018 and 2022.…”

Section: Introductionmentioning

confidence: 99%

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Brown spiders (Loxosceles) are taking hold in Pernambuco, Brazil: a case series, 2018-2022

Amorim,

Simão,

Albuquerque

et al. 2024

Epidemiol. Serv. Saúde

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Objective To describe accidents involving brown spider (genus Loxosceles) bites notified by the Pernambuco Poison Information and Care Center (CIATox-PE), Brazil, from January 2018 to December 2022. Methods This was a case series study of brown spider bites notified by the CIATox-PE. Results The study included 22 cases with median age of 35 years, the majority being female (13); the cases occurred in rural and urban areas (12 versus 10), at night (10); Petrolina was the municipality with the highest number of notifications (6); spider bites occurred mainly in the lower (11) and upper (9) limbs, almost exclusively inside households (21); specific serum therapy was not indicated for 8 cases because the time for its effectiveness had already elapsed. Conclusion Loxoscelism cases occurred more frequently in females, in both rural and urban areas and mainly at home, with delays in seeking medical care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brown spiders (Loxosceles) are taking hold in Pernambuco, Brazil: a case series, 2018-2022

Amorim,

Simão,

Albuquerque

et al. 2024

Epidemiol. Serv. Saúde

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“…Animais peçonhentos são animais que, além de produzirem veneno próprio -característica dos animais venenososconseguem inoculá-lo em uma vítima ou quando se sentem ameaçados, ou para afastar predadores ou para capturar a presa (Souza et al 2022). Dentre as estruturas que inoculam o veneno, há dentes ocos, espinhos e ferrões.…”

Section: Introductionunclassified

Ataques de animais peçonhentos no Pará: Correlação entre óbitos e soroterapia no contexto da urgência e emergência

Rocha,

Dias,

Mineshita

et al. 2024

RSD

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Os ataques por animais peçonhentos consistem em uma problemática importante para saúde pública, sobretudo em regiões predominantemente rurais, as quais são mais sujeitas a conter um maior número desses animais. Assim, são necessários eficazes protocolos em caso de ataques de animais peçonhentos, uma vez que a soroterapia é o tratamento mais indicado e os soros precisam estar disponíveis no momento do atendimento a essas vítimas. A seguinte produção tem como objetivo correlacionar a evolução do caso de pacientes vítimas de ataques por animais peçonhentos com o tempo entre o ataque e o atendimento, bem como à aplicação da soroterapia, especificamente no estado do Pará. É um estudo quantitativo, analítico, observacional e transversal, no qual foram utilizados dados sobre ataques de animais peçonhentos de 2013 até 2022 no estado do Pará coletados no Departamento de Informática do Sistema Único de Saúde. Foi verificado que os melhores prognósticos estavam entre os pacientes que procuraram atendimento médico com uso da soroterapia de 1 a 3 horas após a picada, evoluindo para cura total, enquanto os que procuravam atendimento 6 horas após a picada possuíam maiores índices de óbito. Além disso, apesar da irregularidade dos casos no período analisado, o fator tempo de atendimento após a picada, aliado com o uso da soroterapia, representou melhores prognósticos, com taxas de cura total de aproximadamente 84% com o tempo de resposta ideal sendo de 1 hora após o ataque.

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“…Bothrops genus is the major perpetrating group of snakes causing SBE in Brazil, and Bothrops atrox ( B. atrox ) is responsible for most cases in the Amazon region [ 5 , 6 , 7 , 8 ]. The envenoming caused by this species is evidenced by several local manifestations comprised by pain, edema, increased local temperature and erythema, and it may evolve to severe complications related to tissue injury with possible long-term disabilities [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Profile Associated with Secondary Infection from Bothrops atrox Snakebites in the Brazilian Amazon

Cavalcante,

de Souza,

Neves

et al. 2023

Toxins

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Bothrops snakebite envenomation (SBE) is consider an important health problem in Brazil, where Bothrops atrox is mainly responsible in the Brazilian Amazon. Local effects represent a relevant clinical issue, in which inflammatory signs and symptoms in the bite site represent a potential risk for short and long-term disabilities. Among local complications, secondary infections (SIs) are a common clinical finding during Bothrops atrox SBE and are described by the appearance of signs such as abscess, cellulitis or necrotizing fasciitis in the affected site. However, the influence of SI in the local events is still poorly understood. Therefore, the present study describes for the first time the impact of SBE wound infection on local manifestations and inflammatory response from patients of Bothrops atrox SBE in the Brazilian Amazon. This was an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus (Brazil), involving victims of Bothrops SBE. Clinical and laboratorial data were collected along with blood samples for the quantification of circulating cytokines and chemokines before antivenom administrations (T0) and 24 h (T1), 48 h (T2), 72 h (T3) and 7 days after (T4). From the 94 patients included in this study, 42 presented SI (44.7%) and 52 were without SI (NSI, 55.3%). Patients classified as moderate envenoming presented an increased risk of developing SI (OR = 2.69; CI 95% = 1.08–6.66, p = 0.033), while patients with bites in hands showed a lower risk (OR = 0.20; CI 95% = 0.04–0.96, p = 0.045). During follow-up, SI patients presented a worsening of local temperature along with a sustained profile of edema and pain, while NSI patients showed a tendency to restore and were highlighted in patients where SI was diagnosed at T2. As for laboratorial parameters, leukocytes, erythrocyte sedimentation ratio, fibrinogen and C-reactive protein were found increased in patients with SI and more frequently in patients diagnosed with SI at T3. Higher levels of circulating IL-2, IL-10, IL-6, TNF, INF-γ and CXCL-10 were observed in SI patients along with marked correlations between these mediators and IL-4 and IL-17, showing a plurality in the profile with a mix of Th1/Th2/Th17 response. The present study reports for the first time the synergistic effects of local infection and envenoming on the inflammatory response represented by local manifestations, which reflected on laboratorial parameters and inflammatory mediators and thus help improve the clinical management of SI associated to Bothrops SBE.

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Tendência temporal e perfil epidemiológico dos acidentes por animais peçonhentos no Brasil, 2007-2019

Cited by 7 publications

References 21 publications

Brown spiders (Loxosceles) are taking hold in Pernambuco, Brazil: a case series, 2018-2022

Brown spiders (Loxosceles) are taking hold in Pernambuco, Brazil: a case series, 2018-2022

Ataques de animais peçonhentos no Pará: Correlação entre óbitos e soroterapia no contexto da urgência e emergência

Inflammatory Profile Associated with Secondary Infection from Bothrops atrox Snakebites in the Brazilian Amazon

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