Tendency toward increase in the frequency of isolation of β-lactamase-nonproducing Neisseria gonorrhoeae exhibiting penicillin resistance, and recent emergence of multidrug-resistant isolates in Japan

Kobayashi, Ichiro; Kanayama, Akiko; Saika, Takeshi; Nishida, Motohiro; Nakayama, Hiroshi; Tanaka, Masatoshi; Naito, Seiji

doi:10.1007/s10156-002-0229-z

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Although b-lactamases are associated with resistance to b-lactams in organisms such as H. influenzae and Neisseria spp., increasingly, non-b-lactamase resistance to these agents is seen in H. influenzae [259], Neisseria gonnorhoeae [260] and Neisseria meningitidis [261], possibly due to alterations in PBPs. Indeed, mutations in PBP genes have been reported in b-lactam-resistant strains of these organisms (H. influenzae [262 -265], N. gonorrhoeae [266][267][268] and N. meningitidis [269 -271]), including strains resistant to extended-spectrum cephalosporins [263,267,268].…”

Section: Gram-negative Organismsmentioning

confidence: 99%

Resistance to ?-lactam antibiotics

Poole

2004

CMLS, Cell. Mol. Life Sci.

291

218

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beta-lactams have a long history in the treatment of infectious diseases, though their use has been and continues to be confounded by the development of resistance in target organisms. beta-lactamases, particularly in Gram-negative pathogens, are a major determinant of this resistance, although alterations in the beta-lactam targets, the penicillin-binding proteins (PBPs), are also important, especially in Gram-positive pathogens. Mechanisms for the efflux and/or exclusion of these agents also contribute, though often in conjunction these other two. Approaches for overcoming these resistance mechanisms include the development of novel beta-lactamase-stable beta-lactams, beta-lactamase inhibitors to be employed with existing beta-lactams, beta-lactam compounds that bind strongly to low-affinity PBPs and agents that potentiate the activity of existing beta-lactams against low-affinity PBP-producing organisms.

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Section: Gram-negative Organismsmentioning

confidence: 99%

Resistance to ?-lactam antibiotics

Poole

2004

CMLS, Cell. Mol. Life Sci.

291

218

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“…В целом наибольшую частоту устойчивости к пенициллину (до 80-90%) наблюдают в юго-Восточной Азии и Африке, при этом в ряде стран наиболее распространены штаммы, продуцирующие β-лактамазы. Однако преобладающей тенденцией последних лет является рост распространенности штаммов с хромосомными механизмами устойчивости [31,32].…”

Section: этиотропная терапия гонореи характеристика препаратов и расп...unclassified

Cephalosporins of the third generation for the treatment of gonorrhea

Frigo¹,

Guchev²,

Сидоренко³

et al. 2011

Vestnik dermatologii i venerologii

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The article presents the data on antibiotic resistance and N. gonorrhoeae mechanisms for developing resistance to antimicrobial drugs belonging to different pharmacologic groups and applied for causal treatment of gonorrhea. The article proves the key problem related to the treatment of gonococcal infection in Russia lies in the prevalence of strains being resistant to most of the antibacterial drugs that used to be applied in the clinical practice on a broad scale and efficiently. So, cephalosporins of the third generation are presently the only drug type that N. gonorrhoeae remains sensitive to. Their application ensures the maximum efficacy against the gonococcal infection. According to the presentday international recommendations complying with the WHO criteria as well as accumulated experience, cefixime, a drug belonging to cephalosporins of the third generation, can be a drug of choice for the antibacterial therapy of gonorrhea along with ceftriaxon.

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Tetracyclines and Chloramphenicol

Salvatore¹,

Meyers²

2010

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

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Tendency toward increase in the frequency of isolation of β-lactamase-nonproducing Neisseria gonorrhoeae exhibiting penicillin resistance, and recent emergence of multidrug-resistant isolates in Japan

Cited by 4 publications

References 20 publications

Resistance to ?-lactam antibiotics

Resistance to ?-lactam antibiotics

Cephalosporins of the third generation for the treatment of gonorrhea

Tetracyclines and Chloramphenicol

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