Tendinosis-like changes in denervated rat Achilles tendon

El-Habta, Roine; Chen, Jialin; Pingel, Jessica; Backman, Ludvig J.

doi:10.1186/s12891-018-2353-7

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Achilles tendon may be particularly prone to rebound increase in ruptures following periods of inactivity given its unique anatomical and functional structure [ 11 , 17 ]. Multiple animal model studies have demonstrated tendinosis-like microscopic changes in the unloaded Achilles tendon, either through immobilization or denervation [ 5 , 6 , 8 , 9 , 17 ]. Tendon physiology and composition has been shown to respond to the level of mechanical load being applied 3 .…”

Section: Discussionmentioning

confidence: 99%

Increased incidence of acute achilles tendon ruptures in the peri-pandemic COVID era with parallels to the 2021–22 NFL season

Azam²,

Butler³

et al. 2023

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Purpose Acute Achilles tendon ruptures (AATRs) are a common sporting injury, whether for recreational athletes or elite athletes. Prior research has shown returning to physical activity after extended periods of inactivity leads to increased rates of musculoskeletal injuries. The purpose of this study was to investigate rates of acute Achilles’ tendon ruptures at a single academic institute in the peri-COVID era, with corollary to the recent NFL season. Methods A retrospective search was conducted using current procedural terminology to identify the total number of Achilles acute primary repair surgeries performed from years 2017 to 2021. Non-operatively managed AATRs were identified from the same electronic medical record using ICD-10 codes. NFL data were obtained from publicly available sites according to previously validated studies. Results A total of 588 patients who sustained AATRs and underwent primary surgical repair were identified, primarily men (75.7%, n = 445), with an average age of 43.22 ± 14.4 years. The number and corresponding incidence of AATR repairs per year was: 2017: n = 124 (21.1%), 2018: n = 110 (18.7%), 2019: n = 130 (22.1%), 2020: n = 86 (14.6%), 2021: n = 138 (23.5%), indicating a 7.5% decrease in rate of AATRs from 2019 to 2020, followed by an 8.9% increase in incidence from 2020 to 2021. Within the NFL, the number of AATRs resulting in an injured reserve stint increased every regular season from 2019 to 2020: n = 11 (21.2%), to 2020–2021: n = 17 (32.7%), to this past 2021–2022 season: n = 24 (46.2%). Conclusion AATR surgeries seem to have increased in 2021 following a 2020 COVID pandemic-induced quarantine for recreational athletes at a single academic institution and for professional athletes in the NFL, although these results are of questionable clinical significance. This provides prognostic information when counseling patients and athletes on return to activity or sport. Level of evidence Level IV.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased incidence of acute achilles tendon ruptures in the peri-pandemic COVID era with parallels to the 2021–22 NFL season

Azam²,

Butler³

et al. 2023

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

show abstract

“…Chronic Achilles tendinopathy is more common in older people than in young people. The pain is related to an alteration of the mechanical properties of tension and rigidity of the aponeurosis of the Achilles tendon [6,7] . The risk factors of Achilles tendinopathy can be divided into intrinsic and extrinsic factors.…”

Section: Achilles Tendinopathymentioning

confidence: 99%

“…The retrocalcaneal bursa is saddled over the posteriorsuperior prominence of the calcaneus under the Achilles tendon and its lateral expansions. At this site the bursa and the bone are so intimately related that a prominence of the calcaneum will greatly predispose to mechanical irritation of the bursa and the tendon [7] .…”

Section: Retrocalcaneal Bursitismentioning

confidence: 99%

Heel pain: A systematic review with homoeopathic management

Mev¹,

Nama²,

Sharma³

et al. 2021

Int. J. Homoeopathic Sci.

View full text Add to dashboard Cite

Heel pain is a very common foot disease that may cause significant discomfort and disability. Biomechanic factors are the most common etiology that can induce mild to moderate chronic heel pain. Common conditions related with heel pain includes: plantar fasciitis, calcaneal spur, sever's disease, Achilles tendinopathy, heel bursitis. Location of pain can guide the proper diagnosis for the particular variety of heel pain. This review presents the current state of knowledge regarding various varieties of heel pain, including relevant anatomy, biomechanics, epidemiology, etiopathology, clinical manifestations. And role of homoeopathic medicines in the management of different conditions related with heel pain.

show abstract

“…It cannot account for the observation that a denervated tendon, which is subjected to passive loading exhibits degenerative features in comparison with a tendon that is loaded by muscle contraction. 12 This highlights the potential role of the muscle-derived secretome in enhancing tendon healing.…”

Section: Introductionmentioning

confidence: 95%

Secretome from myoblasts statically loaded at low intensity promotes tenocyte proliferation via the IGF‐1 receptor pathway

Li,

Zhou,

Chen

et al. 2023

The FASEB Journal

Self Cite

View full text Add to dashboard Cite

Exercise is widely recognized as beneficial for tendon healing. Recently, it has been described that muscle‐derived molecules secreted in response to static exercise influence tendon healing. In this study, the optimal static loading intensity for tendon healing and the composition of secretome released by myoblasts in response to different intensities of static strain were investigated. In an in vitro coculture model, myoblasts were mechanically loaded using a Flexcell Tension System. Tenocytes were seeded on transwell inserts that allowed communication between the tenocytes and myoblasts without direct contact. Proliferation and migration assays, together with RNA sequencing, were used to determine potential cellular signaling pathways. The secretome from myoblasts exposed to 2% static loading increased the proliferation and migration of the cocultured tenocytes. RNA‐seq analysis revealed that this loading condition upregulated the expression of numerous genes encoding secretory proteins, including insulin‐like growth factor‐1 (IGF‐1). Confirmation of IGF‐1 expression and secretion was carried out using qPCR and enzyme‐linked immunosorbt assay (ELISA), revealing a statistically significant upregulation in response to 2% static loading in comparison to both control conditions and higher loading intensities of 5% and 10%. Addition of an inhibitor of the IGF‐1 receptor (PQ401) to the tenocytes significantly reduced myoblast secretome‐induced tenocyte proliferation. In conclusion, IGF‐1 may be an important molecule in the statically loaded myoblast secretome, which is responsible for influencing tenocytes during exercise‐induced healing.

show abstract

Tendinosis-like changes in denervated rat Achilles tendon

Cited by 7 publications

References 29 publications

Increased incidence of acute achilles tendon ruptures in the peri-pandemic COVID era with parallels to the 2021–22 NFL season

Increased incidence of acute achilles tendon ruptures in the peri-pandemic COVID era with parallels to the 2021–22 NFL season

Heel pain: A systematic review with homoeopathic management

Secretome from myoblasts statically loaded at low intensity promotes tenocyte proliferation via the IGF‐1 receptor pathway

Contact Info

Product

Resources

About