Tendon Fascicles Exhibit a Linear Correlation Between Poisson's Ratio and Force During Uniaxial Stress Relaxation

Reese, Shawn P.; Weiss, Jeffrey A.

doi:10.1115/1.4023134

Cited by 41 publications

(33 citation statements)

References 38 publications

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“…54 This suggests that fiber crimping affects the lateral contraction of scaffolds and native tissue during loading, which is an important determinant of the tissue time-dependent mechanical behavior. 55 Together, these results demonstrate that electospun PLLA scaffolds can be produced to mimic the fibrous microstructure and nonlinear mechanics of native tendons and ligaments.…”

Section: Discussionmentioning

confidence: 64%

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

Szczesny¹,

Driscoll²,

Tseng

et al. 2016

ACS Biomater. Sci. Eng.

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To fully recapitulate tissue microstructure and mechanics, fiber crimping must exist within biomaterials used for tendon/ligament engineering. Existing crimped nanofibrous scaffolds produced via electrospinning are dense materials that prevent cellular infiltration into the scaffold interior. In this study, we used a sacrificial fiber population to increase the scaffold porosity and evaluated the effect on fiber crimping. We found that increasing scaffold porosity increased fiber crimping and ensured that the fibers properly uncrimped as the scaffolds were stretched by minimizing fiber−fiber interactions. Constitutive modeling demonstrated that the fiber uncrimping produced a nonlinear mechanical behavior similar to that of native tendon and ligament. Interestingly, fiber crimping altered strain transmission to the nuclei of cells seeded on the scaffolds, which may account for previously observed changes in gene expression. These crimped biomaterials are useful for developing functional fiberreinforced tissues and for studying the effects of altered fiber crimping due to damage or degeneration.

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Section: Discussionmentioning

confidence: 64%

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

Szczesny¹,

Driscoll²,

Tseng

et al. 2016

ACS Biomater. Sci. Eng.

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“…7). A helical arrangement of fascicles is reported in the equine SDFT (Thorpe et al, 2013a;Thorpe et al, 2014;Thorpe et al, 2015b), the human Achilles (Szaro et al, 2009) and extensor carpi ulnaris tendon (Kalson et al, 2012), bovine flexor and rat tail tendon (de Campos Vidal, 2003;Reese and Weiss, 2013), canine patellar tendon and anterior cruciate ligament (Yahia and Drouin, 1989). Collagen fibres (fibril bundles) in chick metatarsal tendon and mouse Achilles and tail tendon appear to define tendon crimp which governs the non-linearity of the tendon stress-strain curve (Kalson et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Variations during ageing in the three-dimensional anatomical arrangement of fascicles within the equine superficial digital flexor tendon

Ali¹,

Comerford²,

Clegg³

et al. 2018

eCM

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Tendons are constructed from collagenous fascicles separated by endotenon/interfascicular matrix (IFM). Tendons may be specialised for precision movement or to store energy during locomotion and for the latter the elasticity of the endotenon/IFM is particularly important. The equine superficial digital flexor tendon (SDFT) is a dedicated energy-storing tendon with a similar function to the human Achilles tendon. Classical anatomical descriptions portray fascicles as longitudinally arranged distinct anatomical structures. In the present study, using three-dimensional reconstruction from whole tissue slices and histological sections, the fascicles of the equine SDFT were found to adopt a complex interweaved arrangement. Fascicles were found to fully and partially converge and diverge within the tendon and fascicle bundles were observed. Fascicle morphology was not homogenous with narrowing, broadening and twisted fascicles observed in addition to relatively straight fascicles. The number of fascicle bundles observed in cross-section increased from the proximal to the distal end of the tendon, whilst the number of fascicles decreased with age in the proximal region. Fascicular patterns were not similar between the left and right limbs, across different regions or at different ages. A decrease in thickness of the endotenon/IFM between fascicles with age was found in the distal tendon region. The results provide a rationale for considering fascicular organisation when diagnosing and treating tendon injuries, for bioengineering tendon and when modelling tendon function.

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“…A few studies have also investigated the Poisson's ratio of tendons, both experimentally [2,[14][15][16][17][18][19] and numerically [20,21]. The Poisson's ratio [22] is a fundamental material property in its own accord and describes the change in size of a system in a direction perpendicular to an applied stress.…”

Section: Introductionmentioning

confidence: 99%

Negative Poisson’s ratios in tendons: An unexpected mechanical response

et al. 2015

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We report that human tendons including the Achilles tendons exhibits the very unusual mechanical property of a negative Poisson's ratio (auxetic) meaning that they get fatter rather than thinner when stretched. This report is backed by in vivo and ex vivo experiments we performed which clearly confirm auxeticity in this living material for strains which correspond to those experienced during most normal everyday activities. We also show that this property is not limited to the human Achilles tendon, as it was also found in tendons taken from sheep and pigs. This new information about tendons can form the scientific basis for a test for tendon health as well as enable the design of better tendon prosthesis which could replace damaged tendons.

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Tendon Fascicles Exhibit a Linear Correlation Between Poisson's Ratio and Force During Uniaxial Stress Relaxation

Cited by 41 publications

References 38 publications

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

Variations during ageing in the three-dimensional anatomical arrangement of fascicles within the equine superficial digital flexor tendon

Negative Poisson’s ratios in tendons: An unexpected mechanical response

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