Tendon Healing

Meulen, Jacques C. van der; Leistikow, Paul Antoine

doi:10.1016/s0094-1298(20)30549-6

Cited by 13 publications

(1 citation statement)

References 98 publications

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“…At the histological level, mature tendon appears as a dense, regular connective tissue composed of fibrous protein, amorphous ground substance, tenocytes and blood vessels (Gillard et al., 1977; Junqueira et al.,1989; Oryan, 1995; Oryan and Peyghan, 1996). Biochemical and ultrastructural studies have revealed that the collagen content increases with maturation and ageing of the tissue (Van Der Meulen and Leistikow, 1977; Ippolito et al., 1980; Scott et al., 1981). A quantitative ultrastructural study in rat has also shown that collagen fibril diameters display a sharp unimodal distribution at birth, which becomes bimodal at 12 weeks of age (Moore and De Beaux, 1987).…”

Section: Introductionmentioning

confidence: 99%

Histology and Ultrastructure of the Developing Superficial Digital Flexor Tendon in Rabbits

Oryan¹,

Shoushtari²

2007

Anat Histol Embryol

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This study was designed to investigate the developmental changes in the superficial digital flexor tendon (SDFT) of the white New Zealand rabbit, from 5 to 7 days pre-natal to 112 days post-natal (PN), at histological and ultrastructural levels. The tendons changed from being highly cellular with 13079 +/- 2538 cell/mm(2) and little directional organization to a longitudinally oriented, predominantly connective tissue structure with relatively few, mature tenocytes (2384 +/- 365 cell/mm(2)). Fibrillogenesis was seen in isolated vacuoles of fibroblast cytoplasm during fetal life as well as after birth, but less frequently with increasing age. At the ultrastructural level, there was a progressive increase in the mean diameter of collagen fibrils with age throughout the population, until PN day 28. A bimodal distribution of collagen fibril size was first observed on PN day 56 while at day 112, the fibrils were fully differentiated and showed a multimodal size distribution. The development of elastic fibres preceded that of collagen fibres and accompanied progressively more marked sinusoidal crimping in collagen fibres on PN days 7 and 14. The tendons of older animals became less tightly crimped. The cells of the epi- and endotenon were less mature and relatively undifferentiated compared with the cells in the body of the tendon of the same age, which might explain their ability to initiate healing of tendon injuries in older animals. In conclusion, extensive changes were observed in tendons during growth and maturation, with diameters of collagen fibrils, tissue orientation and cellularity being the parameters affected, probably due largely to increased physical activity.

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Section: Introductionmentioning

confidence: 99%

Histology and Ultrastructure of the Developing Superficial Digital Flexor Tendon in Rabbits

Oryan¹,

Shoushtari²

2007

Anat Histol Embryol

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A biomechanical study of tendon adhesion reduction using a biodegradable barrier in a rabbit model

Meislin

Wiseman

Alexander

et al. 1990

J of Applied Biomaterials

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Adhesion formation associated with tendon surgery is a widespread problem in which a healing tendon becomes adherent via scar tissue to surrounding structures such as bone, muscle, skin, tendon sheath, or other tendons. A model is described in which adhesions were generated reproducibly between the plantaris and Achilles tendons of the rabbit using a partial tenotomy, a Bunnel suture, and immobilization. Using this model, the effect of an absorbable barrier, INTERCEED (TC7), on adhesion formation was investigated. This material, which is a fabric comprised of oxidized regenerated cellulose, was found to diminish significantly the extent and severity of intertendinous adhesions, assessed both mechanically and histologically. No evidence of a foreign body reaction was observed.

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The impact of polyglycolide membrane on a tendon after surgical rejoining. A histological and histomorphometric analysis in rabbits

Pihlajamäki

Tynninen

Karjalainen

et al. 2007

J Biomedical Materials Res

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Tissue response to self-reinforced polyglycolide (SR-PGA) membranes surrounding rejoined rabbit tendons was compared with tissue response to nonenveloped rejoined tendons, with special focus on scar formation and SR-PGA membrane biodegradation process. Both hind legs of 20 skeletally mature rabbits were operated on by transecting the plantaris longus tendons and rejoining the ends with sutures. The right side seams were enveloped with bioabsorbable SR-PGA membranes, while the left sides served as noncovered controls. The follow-up times were 3, 6, 12, and 24 weeks. Scar formation and tissue response to membranes were studied by histological and histomorphometric analysis. Tendon regeneration was most active at 3 weeks. Capillary formation was more prominent in specimens with shorter follow-up times. Membrane degradation induced an inflammatory reaction observed at all follow-up time points. Under polarizing microscopy, birefringent SR-PGA material was seen to vanish almost completely by 24 weeks. SR-PGA membranes had no specific effect on scar formation and there were no differences in the reunion process of the transected tendon ends between the SR-PGA membrane groups and the controls. Inflammatory cells in the SR-PGA membrane groups reflected a tissue reaction to the membrane. When placed in soft tissues, SR-PGA membranes degraded almost completely within 24 weeks.

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Tendon Healing

Cited by 13 publications

References 98 publications

Histology and Ultrastructure of the Developing Superficial Digital Flexor Tendon in Rabbits

Histology and Ultrastructure of the Developing Superficial Digital Flexor Tendon in Rabbits

A biomechanical study of tendon adhesion reduction using a biodegradable barrier in a rabbit model

The impact of polyglycolide membrane on a tendon after surgical rejoining. A histological and histomorphometric analysis in rabbits

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