2019
DOI: 10.3389/fnins.2019.00177
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Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What’s Known in Fish?

Abstract: Teneurins have well established roles in function and maintenance of the central nervous systems of vertebrates. In addition, teneurin c-terminal associated peptide (TCAP), a bioactive peptide found on the c-terminal portion of teneurins, has been shown to regulate glucose metabolism. Although, the majority of research conducted on the actions of teneurins and TCAPs has strictly focused on neurological systems in rodents, TCAP was first identified in rainbow trout after screening trout hypothalamic cDNA. This … Show more

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“…There are four teneurin homologs that have been identified in vertebrates and one additional homologue has been identified in zebrafish (Danio rerio) as they contain 5 known teneurins-1, 2a, 2b, 3, and 4 (Mieda et al, 1999;Tucker et al, 2012). The identification of teneurin sequences in several teleost species was recently reviewed (Reid et al, 2019). All teneurin proteins include a conserved peptide sequence at the extracellular distal terminus, called teneurin C-terminal associated peptide (TCAP), first identified in rainbow trout (Oncorhynchus mykiss) (Qian et al, 2004;Wang et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…There are four teneurin homologs that have been identified in vertebrates and one additional homologue has been identified in zebrafish (Danio rerio) as they contain 5 known teneurins-1, 2a, 2b, 3, and 4 (Mieda et al, 1999;Tucker et al, 2012). The identification of teneurin sequences in several teleost species was recently reviewed (Reid et al, 2019). All teneurin proteins include a conserved peptide sequence at the extracellular distal terminus, called teneurin C-terminal associated peptide (TCAP), first identified in rainbow trout (Oncorhynchus mykiss) (Qian et al, 2004;Wang et al, 2005).…”
Section: Introductionmentioning
confidence: 99%