Tenosynovial Giant Cell Tumor, Localized Type With Extensive Chondroid Metaplasia: A Case Report With Immunohistochemical and Molecular Genetic Analysis

Nagase, Mamiko; Araki, Asuka; Ishikawa, Noriyoshi; Nagano, Nahoko; Fujimoto, Makiko; Biyajima, Kyoko; Yamagami, Nobuo; Yamamoto, Sachiko; Maruyama, Riruke

doi:10.1177/1066896919889672

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…We noted that the Contegra group was characterized by hyalinosis, and subintimal chondroid metaplasia with signs of calcification both in the graft wall and PA in the anastomotic area (Figures 4B and 6). These transformations were confirmed via Von Kossa staining and IHC staining for S100 protein [44][45][46]. Previously, Peivandi et al described foci of heterotopic ossification in Contegra conduits 9 years after implantation [36].…”

Section: Discussionmentioning

confidence: 77%

Epoxy- versus Glutaraldehyde-Treated Bovine Jugular Vein Conduit for Pulmonary Valve Replacement: A Comparison of Morphological Changes in a Pig Model

Nichay,

Dokuchaeva,

Kulyabin

et al. 2023

Biomedicines

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Valved conduits are often required to replace pulmonary arteries (PA). A widely used Contegra device is made of bovine jugular vein (BJV), preserved with glutaraldehyde (GA) and iso-propanol. However, it has several drawbacks that may be attributed to its chemical treatment. We hypothesized that the use of an alternative preservation compound may significantly improve BJV conduit performance. This study aimed to compare the macroscopic and microscopic properties of the BJV treated with diepoxide (DE) and GA in a porcine model. Twelve DE-BJVs and four Contegra conduits were used for PA replacement in minipigs. To assess the isolated influence of GA, we included an additional control group—BJV treated with 0.625% GA (n = 4). The animals were withdrawn after 6 months of follow-up and the conduits were examined. Explanted DE-BJV had a soft elastic wall with no signs of thrombosis or calcification and good conduit integration, including myofibroblast germination, an ingrowth of soft connective tissue formations and remarkable neoangiogenesis. The inner surface of DE-BJVs was covered by a thin neointimal layer with a solid endothelium. Contegra grafts had a stiffer wall with thrombosis on the leaflets. Calcified foci, chondroid metaplasia, and hyalinosis were observed within the wall. The distal anastomotic sites had hyperplastic neointima, partially covered with the endothelium. The wall of GA-BJV was stiff and rigid with degenerative changes, a substantial amount of calcium deposits and dense fibrotic formations in adventitia. An irregular neointimal layer was presented in the anastomotic sites without endothelial cover in the GA BJV wall. These results demonstrate that DE treatment improves conduit integration and the endothelialization of the inner surface while preventing the mineralization of the BJV, which may reduce the risk of early conduit dysfunction.

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Section: Discussionmentioning

confidence: 77%

Epoxy- versus Glutaraldehyde-Treated Bovine Jugular Vein Conduit for Pulmonary Valve Replacement: A Comparison of Morphological Changes in a Pig Model

Nichay,

Dokuchaeva,

Kulyabin

et al. 2023

Biomedicines

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“…Chondroid metaplasia can infrequently be seen and was extensive in a few reports, showing a predilection for the temporomandibular joint. 9,10 Separation from CCMN can be challenging 19 and relies on the detection of the characteristic features of tenosynovial giant cell tumor, including histiocytic and mononuclear cell proliferation, and low-power identification of an expansile mass with diffuse and/or villous growth (in the diffuse type), as well as molecular analysis for CSF1 translocations in select cases. We note that 5 cases in the Liu et al series and 1 case in our series involved the TMJ, which raises the possibility that so-called tenosynovial giant cell tumors with chondroid metaplasia represents CCMN arising in the TMJ given the significant morphologic overlap and presence of FN1 rearrangements in the majority of cases.…”

Section: Discussionmentioning

confidence: 99%

Calcified Chondroid Mesenchymal Neoplasm

Kallen

Meyer

Suster

et al. 2023

American Journal of Surgical Pathology

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Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma.

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“…Synovial giant cell tumor most frequently occurs on the hand and uncommonly on the ankle or knee [ 1 ]. Tenosynovial giant cell tumor (TSGCT) is a family of lesions involving the joint synovia, bursae, and tendon sheath [ 2 ]. TSGCT is considered rare and has an incidence of 43 cases per million population per year and typically affects young patients in the third and fourth decades [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Tenosynovial Giant Cell Tumor After ACL Reconstruction With Autograft

Booth¹,

McDonough²

2022

Cureus

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A 25-year-old male developed left knee pain several years after anterior cruciate ligament (ACL) reconstruction. MRI showed a suspected cyclops lesion over the anterior portion of the knee. The patient underwent diagnostic knee arthroscopy with lesion removal, and it was discovered the patient had a tenosynovial giant cell tumor. A tenosynovial giant cell tumor is a rare intraarticular lesion that requires a high suspicion for clinical diagnosis. Management is currently centered around arthroscopic versus open removal of the lesion with serial monitoring and advanced imaging for recurrence.

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Tenosynovial Giant Cell Tumor, Localized Type With Extensive Chondroid Metaplasia: A Case Report With Immunohistochemical and Molecular Genetic Analysis

Cited by 7 publications

References 23 publications

Epoxy- versus Glutaraldehyde-Treated Bovine Jugular Vein Conduit for Pulmonary Valve Replacement: A Comparison of Morphological Changes in a Pig Model

Epoxy- versus Glutaraldehyde-Treated Bovine Jugular Vein Conduit for Pulmonary Valve Replacement: A Comparison of Morphological Changes in a Pig Model

Calcified Chondroid Mesenchymal Neoplasm

Tenosynovial Giant Cell Tumor After ACL Reconstruction With Autograft

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