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Background: The localized form is characterized by local participation of the synovium as a nodule or pedunculated mass. The incidence rate of PVNS is estimated to be 1.8 per million people – the localized type is just one-quarter of that. The aim of this study is to remind orthopedic surgeons about the unusual properties of LPVNS located in the knee. Case Report: A 39-year-old man presented to our clinic with pain and discomfort in his right knee. Magnetic resonance imaging showed an intra-articular mass in the infrapatellar region of the knee adjacent to the Hoffa fat pad. The mass was hypointense in the T1 sequence and heterogeneously hyperintense in the T2 sequence, which may be considered a local type of tenosynovial giant cell tumor (LPVNS). Excision was carefully performed without penetrating the tumor. The macroscopic appearance of the tumor was yellow-reddish and brown in color. Histopathologic examination revealed pigmented villonodular synovitis of the local type. Conclusion: Even though the LPVNS of the knee is an uncommon intra-articular phenomenon, orthopedic surgeons should not overlook this lesion based on imaging findings, and open excision should be regarded as a reliable treatment option.
Background: The localized form is characterized by local participation of the synovium as a nodule or pedunculated mass. The incidence rate of PVNS is estimated to be 1.8 per million people – the localized type is just one-quarter of that. The aim of this study is to remind orthopedic surgeons about the unusual properties of LPVNS located in the knee. Case Report: A 39-year-old man presented to our clinic with pain and discomfort in his right knee. Magnetic resonance imaging showed an intra-articular mass in the infrapatellar region of the knee adjacent to the Hoffa fat pad. The mass was hypointense in the T1 sequence and heterogeneously hyperintense in the T2 sequence, which may be considered a local type of tenosynovial giant cell tumor (LPVNS). Excision was carefully performed without penetrating the tumor. The macroscopic appearance of the tumor was yellow-reddish and brown in color. Histopathologic examination revealed pigmented villonodular synovitis of the local type. Conclusion: Even though the LPVNS of the knee is an uncommon intra-articular phenomenon, orthopedic surgeons should not overlook this lesion based on imaging findings, and open excision should be regarded as a reliable treatment option.
Background and Aim: A tenosynovial giant cell tumor (TGCT) is a proliferative lesion of the synovial membrane of the joints, tendon sheaths and/or bursae. There are two described subtypes, including the localized and diffuse forms. A TGCT can also be intraarticular or extraarticular. An intraarticular localized tenosynovial giant cell tumor (L-TGCT) of the knee is characterized by nodular hyperplasic synovial tissue that can remain asymptomatic for a long time, but as the mass grows, it may cause mechanical symptoms that may require surgical treatment. The aim of our study is to present a rare case of an L-TGCT of the knee joint treated with an arthroscopic excision. Case Report: We describe the case of a 17-year-old female with pain, swelling and knee locking in the absence of trauma. The magnetic resonance imaging (MRI) displayed a well-circumscribed small mass in the anterior medial compartment, adherent to the infrapatellar fat pad. The lesion presented the typical MRI characteristics of an intraarticular localized TGCT. The patient was treated with an arthroscopic mass removal and partial synovectomy. The gross pathology showed an ovoid nodule that was covered by a fibrous capsule; a histopathology examination confirmed the diagnosis. The patient was able to return to normal daily activities one month after surgery; at the three-year follow-up, she was free of symptoms with no evidence of disease on the MRI. Conclusion: In patients with a small-dimension L-TGCT in the anterior compartment of the knee that presents an MRI pattern and causes mechanical symptoms, an arthroscopic en-bloc excision can be performed that results in good outcomes and a rapid return to preinjury levels.
Tendon Sheath Giant Cell Tumor (TGCT) is a benign tumor that primarily grows within joints and bursae. However, it has a high postoperative recurrence rate, ranging from 15% to 45%. Although radiotherapy may reduce this recurrence rate, its applicability as a standard treatment is still controversial. Furthermore, the pathogenic mechanisms of TGCT are not clear, which limits the development of effective treatment methods. The unpredictable growth and high recurrence rate of TGCT adds to the challenges of disease management. Currently, our understanding of TGCT mainly depends on pathological slice analysis due to a lack of stable cell models. In this study, we first reviewed the medical records of two female TGCT patients who had undergone radiotherapy. Then, by combining bioinformatics and machine learning, we interpreted the pathogenesis of TGCT and its associations with other diseases from multiple perspectives. Based on a deep analysis of the case data, we provided empirical support for postoperative radiotherapy in TGCT patients. Additionally, our further analysis revealed the signaling pathways of differentially expressed genes in TGCT, as well as its potential associations with osteoarthritis and synovial sarcomas.
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