Tenoxicam

Abstract

Tenoxicam is a new non-steroidal anti-inflammatory and analgesic agent of the oxicam class, and therefore closely related to piroxicam. It possesses a long half-life which enables it to be administered once daily. Clinical trials in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout and non-articular rheumatism suggest that tenoxicam 20mg daily is an equally effective anti-inflammatory and analgesic agent compared with piroxicam 20mg daily, and that it is at least as well tolerated. Additionally, a few small studies in rheumatoid arthritis and osteoarthritis suggest that tenoxicam 20mg daily is as effective and as well tolerated as usual therapeutic dosages of diclofenac, ibuprofen, indomethacin and naproxen. Transient mild or moderate gastrointestinal symptoms, in 8% of patients at a dosage of 20mg daily, are the most frequently reported side effects. If further studies confirm the initially favourable efficacy and tolerability findings, particularly the relatively low incidence of adverse effects, tenoxicam can be considered a useful new agent for the symptomatic treatment of rheumatic and inflammatory diseases, and a worthwhile alternative to other non-steroidal anti-inflammatory drugs.

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

“…Presently, non-steroidal anti-inflammatory drugs (NSAIDs) are used as therapeutic treatment [1]. Oxicam is a class of NSAID family, which can be closely attached to plasma proteins and react with metal ions, forming complexes [2]. The formation of oxicam complexes with various metal ions promotes their anti-inflammatory and antimicrobial effects more than free ligands [3][4][5][6].…”

A Comparative Study of the Transdermal Penetration of a Series of Nonsteroidal Antiinflammatory Drugs

“…5,34,35,36 The values obtained for C ss are presented in Table 5. In general, the predicted steady-state plasma concentrations are considerably less than the therapeutic concentrations, as indicated by the high C t /C ss ratios.…”

Polarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol–water mixture

“…A comparative study with respect to aspirin [4], was carried out by Bird et al The efficacy, the mechanisms and the action of the drug as well as its applications have also been described [5].…”