Tensile and stress relaxation characteristics of hybrid PLA-PVA/CS yarns loaded with antibiotic tetracycline hydrochloride used as suture

Moezzi, Meysam; Sa’di, Vida; Ranjbar‐Mohammadi, Marziyeh; Saghafi, Reza; Barez, Fred

doi:10.1080/00405000.2022.2145450

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Not only is PLA bioderived, it is also biocompatible and can be used as a drug delivery support with various therapeutic agents, such as simvastatin for bone regeneration, 20 chemotherapy drugs 21,22 and antibiotics. 23,24 Interestingly, PLA is completely absorbed by the body and the rate of this depends on the molar mass and the stereo-structure of the polymer chains. 25 The mechanical performance and physical properties of PLA, combined with its high degree of biocompatibility, mean that it is particularly well placed for use in a wide variety of drug delivery systems, e.g.…”

Section: Poly(lactic Acid) and Poly(lactide)mentioning

confidence: 99%

Section: Poly(lactic Acid) and Poly(lactide)mentioning

confidence: 99%

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Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Oktavia

Bégué

Campana

et al. 2023

Polymer International

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Since the advent of supporting matrices for biological applications, many types of drugs have been administered via various forms of conventional drug delivery preparations, such as pills, solutions, creams, suppositories, injected gels and so on. Key parameters to all these systems for effective drug delivery are controlled release for sustained periods, targeted delivery, and enhancements of drug stability and efficacy, all of which can be manipulated by using polymers. Given the important impact of the structures of the polymers on these parameters, this mini‐review gives a simple introduction to the requirements of drug delivery systems and surveys the synthetic pathways to a key polymer in this field, namely poly(lactic acid). We also review the preparation of block copolymers that incorporate poly(lactic acid), to expand and further develop its properties for drug delivery systems. It is hoped that this short teacherly and introductory review will provide a basic stepping‐stone to more in‐depth reviews and papers and enable an easy access to this fast growing field. © 2023 Society of Industrial Chemistry.

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