This study examines empirically and theoretically the open-hole tension and compression characteristics of thermoset composites using hybrid glass/polypropylene and glass/innegra yarns. The Abaqus software, finite element analysis (FEA) has been adopted to predict the tensile and compressive failure loads and damage failure modes for un- and notched samples under tensile and compressive strength tests. The commingling technique was used to create hybrid yarns, which were then transformed into non-crimp preforms before the infusion procedure. It was noticed that the inclusion of thermoplastic polypropylene (PP) and innegra fibres increased the ductility of yarns and composites. Densities of hybrid composites were also reduced by up to 20% when compared to pure glass/epoxy composites. Tensile and open-hole tensile (OHT) test results revealed that hybrid composites are less notch sensitive than glass/epoxy composites due to enhanced composite ductility. For glass composites, having holes resulted in a 41% decrease in tensile strength, compared to reductions of only 25% and 26% for PP and innegra fibre composites, respectively. Further, compression and open-hole compression (OHC) tests presented similar results with OHT tests whilst compressive strength reduction was lower for hybrid composites (10% and 11%) compared to glass/epoxy (28%) ones. The results of the numerical simulation for damage failure modes and tensile and compressive failure loads for un-notch and notched composite laminates are consistent with the experimental findings both qualitatively and quantitatively.