The cross-linkable laminating adhesives (LAs) based on core-shell vinyl acetate/acrylate latexes were synthesized through multistage emulsion polymerization. The effects of core copolymer T g , core/shell weight ratio, cross-linking structure and molecular structure on the peel strength of LAs were studied. It was found that peel strength increases with the decrease of core/shell weight ratio and core copolymer T g . And cross-linking structure could improve adhesion properties of LAs evidently. Moreover, the molecular structure of core-shell latexes has a significant influence on adhesion properties of LAs. The peel strength of sample 14-H could reach 3.4 N/15 mm even under 60 C by particle structure design.