To investigate the effect of B4C particle size on the microstructure and mechanical properties of B4C/Al composites, and to provide theoretical guidance for the subsequent thermal processing of composites, B4C/Al composites with varying B4C particle sizes (0.2 ”m, 0.5 ”m, 1 ”m, 10 ”m) were fabricated using pressureless infiltration. The microstructure of the composites was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM), while the mechanical properties were analyzed by hardness test, three-point bending and high temperature compression. The results indicated that Al3BC and AlB2 were the primary interfacial reaction products in B4C/Al composites, and interface reaction could be alleviated with increasing particle size. B4C/Al composites with larger B4C particle sizes exhibited a relatively uniform and discrete distribution of B4C, while those with smaller B4C particle sizes showed agglomeration of B4C. The Vickers hardness and peak flow stress of B4C/Al composites gradually decreased with the increase of B4C particle size, while the bending strength, flexural modulus, and fracture toughness tended to increase. In addition, when B4C particle size was 10 ”m, the composites displayed optimal comprehensive performance with the lowest peak flow stress (150 MPa) and the highest fracture toughness (12.75 MPa·m1/2).