Tensile properties and contours of aging facial skin. A controlled double‐blind comparative study of the effects of retinol, melibiose‐lactose and their association

Piérard-Franchimont, C; Castelli, D.; Cromphaut, I V; Bertin, Christiane; Ries, Gerhard; Cauwenbergh, G.; Pierard, Gérald

doi:10.1111/j.1600-0846.1998.tb00116.x

Cited by 32 publications

(27 citation statements)

References 16 publications

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“…The biological and physical reasons underlying such controversial aspects remain obscure. They have been previously addressed in the literature Piérard-Franchimont et al, 1998). Indeed, in a global view about ageing, the present data are in line with previous findings about altered shear wave propagation in bones (Wang et al, 1983;Chen and Saha, 1987).…”

Section: Fig 2: Uniform Distribution Of the Bmi Throughout The Ages supporting

confidence: 82%

Age- and body mass index-related changes in cutaneous shear wave velocity

Hermanns‐Lê

Jonlet

Scheen

et al. 2001

Experimental Gerontology

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Background: The in vivo visco-elastic characteristics of skin depend on a series of physiopatho-logical parameters. Among them, the age-related intrinsic tensile properties and the preconditioning of the tissues set under tension by the hypodermal volume might be of importance. Aims: To revisit the influence of age and body mass on the firmness and mechanical anisotropy of the skin as determined by the velocity of the shear wave propagation. Method: Resonance running time measurements (RRTM) were performed on the mid volar forearm in 110 adults of both sexes. In each subject 16 RRTM were collected at four different precise angles with regard to the limb axis. We recorded the lowest, the highest and the mean multidirectional RRTM as well as the coefficient of variation (CV) of the latter value. In addition, the body mass index (BMI) was calculated. Results: Age and BMI did not influence the minimum RRTM. In contrast, the maximum RRTM as well as the mean and CV of the multidirectional RRTM, significantly rose in a progressively increasing proportion of the subjects older than 60 years. These changes were only encountered in subjects with a normal BMI ranging from 18 to 25. Sex-related differences were not disclosed. Conclusions: The intrinsic skin tension lines identified by the minimum RRTM are not significantly altered with age and BMI variations. In contrast, skin laxity identified by larger maximum and mean multidirectional RRTM may increase after 60 years of age in subjects with a normal BMI. This is accompanied by increased skin mechanical anisotropy identified by CV values of the multidirectional RRTM over 40%.

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Section: Fig 2: Uniform Distribution Of the Bmi Throughout The Ages supporting

confidence: 82%

Age- and body mass index-related changes in cutaneous shear wave velocity

Hermanns‐Lê

Jonlet

Scheen

et al. 2001

Experimental Gerontology

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“…Piérard-Franchimont et al conducted the first controlled clinical trial with retinol and demonstrated significant improvement in fine wrinkles after 12 weeks of treatment. 57 Varani and colleagues studied 1% retinol on 53 patients with photoaged skin compared with a vehicle control. They found statistically significant histologic improvement at 7 days.…”

Section: Clinical Evidencementioning

confidence: 98%

Reversal of Skin Aging with Topical Retinoids

Hubbard

Unger²,

Rohrich

2014

Plastic &Amp; Reconstructive Surgery

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Topical skin care and its place in plastic surgery today are often overlooked by clinicians formulating a plan for facial rejuvenation. Not only is it important to consider topical skin care as part of comprehensive care, but clinicians should also be educated with the data available in today's literature. This review aims to familiarize the reader with the biological processes of skin aging and evidence-based clinical outcomes afforded by various topical therapies. Furthermore, this review will focus on solar damage, the value of retinoids, and how they can be used in conjunction with forms of treatment such as chemical peel, dermabrasion, and lasers. Finally, guidelines will be provided to help the physician administer appropriate skin care based on the data presented.

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“…Duell and colleagues (1996) demonstrated that retinol could be as effective as retinoic acid in producing ‘retinoid mediated histological changes’ (like epidermal thickening and keratinocyte proliferation), but with much less irritancy. Pierard-Franchimont and colleagues (1998) first conducted a controlled clinical trial with retinol formulation. They observed that retinol formulation resulted in significant improvement in fine wrinkles after 12 weeks of treatment.…”

Section: Retinolmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

420

318

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Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

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Tensile properties and contours of aging facial skin. A controlled double‐blind comparative study of the effects of retinol, melibiose‐lactose and their association

Abstract: ROL, ME-L, and ROL-ME-L formulations improve physical properties of skin that are impaired by aging. Their activities are notably superior to those of a comparative SA formulation.

Cited by 32 publications

References 16 publications

Age- and body mass index-related changes in cutaneous shear wave velocity

Age- and body mass index-related changes in cutaneous shear wave velocity

Reversal of Skin Aging with Topical Retinoids

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

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