Tensile strength of the interface between hydroxyapatite and bone

Lin, Hong; Hengchang, Xu; Groot, K. de

doi:10.1002/jbm.820260103

Cited by 88 publications

(34 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the biomechanical point of view, laminae limitantes are more unstable than mineralized bone matrix and are weak points. Mechanical testing of a variety of implanted biomaterials confirms that the tissue-implant interfacial strength is significantly inferior to the intrinsic strength of bone [Carter and Hayes, 1977;Hong et al, 1992;Wong et al, 1995;Edwards et al, 1997]. Therefore implants with a porous surface are needed for a strong bony fixation.…”

Section: Discussionmentioning

confidence: 99%

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Frosch

Barvencik

Lohmann³

et al. 2002

Cells Tissues Organs

View full text Add to dashboard Cite

The goal of this study was to characterize growth, mineralization and bone formation of osteoblast-like cells in titanium pore channels of defined diameter. Titanium implants with continuous drill channels of diameters of 300, 400, 500, 600 and 1,000 µm were inserted into human osteoblast-like cell cultures. The ingrowth of the cells into the drill channels was investigated by transmitted-light microscopy and scanning electron microscopy. Immunofluorescence and histological analysis of 15-channel sections of each diameter were used to investigate the growth behavior and the matrix protein patterns. Mineralization was evidenced by Alizarin red staining and high-resolution microradiography. The ingrowth of human osteoblast-like cells in the drill channels occurred in a sequence of four characteristic stages. In stage 1, osteoblast precursor cells adhered to the wall of the channel and migrated three-dimensionally into the channel by forming foot-like protoplasmic processes. For all 15 sample drill channels that were investigated, the cell ingrowth over 20 days amounted on average to 793 µm (± 179) into 600-µm-diameter channels, where they migrated significantly faster than in all the other channels. In stage 2, approximately on day 5–7, the osteoblast-like cells began to anchor on the substrate wall by matrix proteins and to build up a dense network of matrix proteins in the drill channel. The mineralization of the extracellular matrix, while depending on cell stimulation, was initiated in stage 3, on average after 4 weeks. In drill channels of a diameter of 1,000 µm the cell growth was incomplete and no mineralization was found by radiological assessment. Starting in week 6, in the drill channels of diameters ranging from 300 to 600 µm, the network of extracellular matrix proteins and osteoblast-like cells began to form an osteon-like structure. Neither the highly developed migration behavior of osteoblastic cells nor the reorganization from a fiber-like matrix to a lamellar structure have so far been described for cell cultures.

show abstract

Section: Discussionmentioning

confidence: 99%

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Frosch

Barvencik

Lohmann³

et al. 2002

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Several studies have demonstrated that BCP is biocompatible with hard tissues and exhibits osteo-conductive properties. [1][2][3][4][5] BCP has been shown to form a direct bond with surrounding tissue after bone implantation. However, it has very poor mechanical properties, which severely limits its use in load-bearing implant applications.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Microstructures and Material Properties in the Vacuum and Spark Plasma Sintered Ti-Calcium Phosphate Composites

Mondal

Sarkar

et al. 2011

Mater. Trans.

View full text Add to dashboard Cite

Sintering of Ti-biphasic calcium phosphate (BCP) is difficult because of the chemical instability of the phases at high temperature. When the sintering temperature is above 1273 K, Ti reacts with BCP and forms CaO, TiO 2 , CaTiO 3 , TiP etc. Conventional vacuum sintering is common for Ti powder but for Ti-BCP composites, spark plasma sintering in an inert atmosphere is a quick method to overcome the issues associated with a prolonged reaction time. In this study, the effect of two different sintering processes on the sintering reactions and mechanical and biological properties of Ti-30 vol%BCP composites were investigated and compared. Detailed micro-structural and morphological analyses were conducted using scanning electron microscopy (SEM). Mechanical properties were characterized by relative density, Vickers hardness and compressive strength measurement. Phase characteristics were analyzed by X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS). Cell viability and biocompatibility were investigated using the MTT assay and by examining cell morphology. In this study, the mechanical properties and biocompatibility for both, spark plasma sintered Ti-Ca-P composites were excellent compare to vacuum sintered composites.

show abstract

“…Two crystalline phases, namely Hibonite -CaO (Al 2 O 3 ) 6 and beta-tricalcium phosphate -Ca 3 (PO 4 ) 2 , with varying peak intensities, can be detected in the patterns. In all cases, the diffractograms have predominantly registered the Hibonite phase -CaO(Al 2 O 3 ) 6 , matched in every sample (ICSD card no. 76-0665), which is due to the dissolution of CaO from HA and its reaction with Al 2 O 3 which makes 50 wt.% in the composite (see Fig.…”

Section: Phase Evaluationmentioning

confidence: 99%

“…Bioceramics of naturally derived biological apatites are more economic. Extensive studies have indicated that HA is biocompatible with hard tissues of human beings and exhibits osteoconductive properties [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Yttria on the Phase Formation and Sintering of HA-Al₂O₃Biocomposites

Öksüz

Özer

2017

Acta Phys. Pol. A

View full text Add to dashboard Cite

Hydroxyapatite is very-well known as the main component of hard tissues and, as such, it has attracted much attention by researchers in the recent decades. This study was aimed to present the characterization of Y2O3 doped 50 wt.% hydroxyapatite -50 wt.% Al2O3 composite materials fabricated at relatively high temperature of 1600• C. Hydroxyapatite powder was obtained from bovine bones via calcination and ball milling technique. Fine powders (≤ 1 µm) of hydroxyapatite/Al2O3 were admixed with 0.5 and 1 wt.% Y2O3 powders. Powder compacts were sintered at 1600• C for 4 h in air atmosphere. The field emission scanning electron microscopy, energy-dispersive spectroscopy and X-ray diffraction studies following the relative density measurements were conducted. Moreover, the microhardness was studied as the mechanical property of sintered samples. The effect of increasing Y2O3 content on surface morphology, elemental distribution and phase evaluation was investigated in hydroxyapatite/Al2O3 biocomposite materials. It was found that by increasing Y2O3 content, the relative density increased up to 98.8%, while the hardness increased to 863 HV (0.2) . The main phases, which were found, are Hibonite -CaO(Al2O3)6 and beta-tricalcium phosphate -Ca3(PO4)2, according to X-ray diffraction pattern.

show abstract

Tensile strength of the interface between hydroxyapatite and bone

Cited by 88 publications

References 5 publications

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Comparative Study of Microstructures and Material Properties in the Vacuum and Spark Plasma Sintered Ti-Calcium Phosphate Composites

Effect of Yttria on the Phase Formation and Sintering of HA-Al₂O₃Biocomposites

Contact Info

Product

Resources

About

Tensile strength of the interface between hydroxyapatite and bone

Cited by 88 publications

References 5 publications

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

Comparative Study of Microstructures and Material Properties in the Vacuum and Spark Plasma Sintered Ti-Calcium Phosphate Composites

Effect of Yttria on the Phase Formation and Sintering of HA-Al2O3Biocomposites

Contact Info

Product

Resources

About

Effect of Yttria on the Phase Formation and Sintering of HA-Al₂O₃Biocomposites