Tensile Strength of Wound Closure with Cyanoacrylate Glue

Shapiro, Andrew J.; Dinsmore, Robert C.; North, James H.

doi:10.1177/000313480106701118

Cited by 86 publications

(8 citation statements)

References 10 publications

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“…However, the UTS for both fibrin sealant types was <8 kPa. For reference, these values were several magnitudes lower than the 50-kPa UTS that is observed with application of cyanoacrylate adhesives (e.g., Dermabond) on the skin [20][21][22][23] and far lower than the 4,400-kPa UTS that is observed with suture pull-out from bovine native articular cartilage. 24 Similarly, the USS for both fibrin sealant types was <30 kPa, which is far lower than the 200 kPa observed with cyanoacrylate adhesives on the skin.…”

Section: Single Application Of Fibrin Sealantmentioning

confidence: 71%

Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair

et al. 2023

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Objective Fibrin sealants are routinely used for intra-articular surgical fixation of cartilage fragments and implants. However, the mechanical properties of fibrin sealants in the context of cartilage repair are unknown. The purpose of this study was to characterize the adhesive and frictional properties of fibrin sealants using an ex vivo model. Design Native bovine cartilage-bone composites were assembled with a single application of Tisseel or Vistaseal. Composites were tested in tension and lap shear. In addition, the coefficient of friction (COF) was measured in a native cartilage annulus model alone and with minced cartilage. Finally, the effect of a double application of fibrin sealant was evaluated. Results There were no significant differences in tensile modulus, ultimate tensile strength (UTS), shear modulus, or ultimate shear strength (USS) between the 2 fibrin sealants. Both fibrin sealants demonstrated a UTS and USS of <8 and <30 kPa, respectively. There were no differences in COF between the sealants when tested alone or with minced cartilage. A double application of fibrin sealant did not alter the mechanical properties compared with a single application of fibrin sealant. Conclusions Fibrin sealant adhesive properties are not affected by the sealant type studied or the number of applications in a bovine cartilage-bone model. Fibrin sealant tribological properties are not affected by sealant type or the addition of minced cartilage. The adhesive properties of Tisseel and Vistaseal were less than those desired for the in vivo fixation of cartilage repair implants. These findings motivate the development of an improved cartilage-specific adhesive for cartilage repair applications.

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Section: Single Application Of Fibrin Sealantmentioning

confidence: 71%

Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair

et al. 2023

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“…Shapiro compared the strength required to disrupt 4 methods of wound closure: 2-octyl cyanoacrylate glue, surgical staples, steri-strips (0.5 inch width), and interrupted 4-0 poliglecaprone subcuticular suture. 7 Staples provided the strongest closure. According to Batra staples was reported to be a good choice for wound closure as they required less time to achieve wound closure and were associated with less pain during the procedure, no pain during removal material, no complications, and greater aesthetic outcome.…”

Section: Discussionmentioning

confidence: 97%

Comparison of tensile strength of skin closure by simple interrupted, simple continuous, and staples

Jarasviriyagul,

Chanasriyotin

2023

Int Surg J

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Background: Objective of the study was to compare tensile strength and time taken for wound closure using simple interrupted sutures, simple continuous sutures, and staples sutures. Methods: Swine skin tissue was cut into pieces of 2×6 cm and were divided into 3 groups according to skin closure technique: simple interrupted sutures (Nylon 5-0), simple continuous sutures (Nylon 5-0), and staples suture. All sutures, three equal knots in one piece, were performed by a single surgeon. Time taken for the approximation of each sample was recorded in second (S). Tensile strength was measured in newton unit (N) by pulling apart until suture separation using a tensiometer. One-way analysis of variance (ANOVA) and subgroup analysis using Bonferroni correction was used to determine differences between groups. Results: Of 190 total pairs of skin tissue, the mean±SD times for skin approximation were 144.86±22.67 s for simple interrupted sutures, 96.19±17.64 s for simple continuous sutures, and 12.90±3.18 s for staples sutures (p<0.001). The corresponding mean±SD of maximum tensile strengths in each group were 29.04±10.72 N, 18.85±5.45 N, and 56.41±19.56 N, respectively (p<0.001). Conclusions: Our study showed that the use of staples for skin approximation took the least operative time and achieved the highest maximum tensile strength.

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“…Their study found comparable strengths of closure between OCA and interrupted subcuticular 4-0 Monocryl, both of which were superior to Steri-Strips and inferior to staples. 23 A thorough search for the tensile strength afforded by ECA-closed wounds was fruitless. Singer et al 21,22 assert that the wound bursting strength of ECA is inferior to that of OCA, referencing their 2004 publication.…”

Section: Applications In Wound Closurementioning

confidence: 99%

Cyanoacrylate Glues for Wilderness and Remote Travel Medical Care

Davis

Derlet

2013

Wilderness & Environmental Medicine

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Cyanoacrylate (CA) glues are commonly used in medical and household repairs. Their chemical compositions have been refined over half a century, making some more suitable than others for creative applications. In remote settings where advanced medical care is not accessible, readily available CAs of differing chemical composition may possess an important therapeutic function. Within this paper we critically examine the published therapeutic risks and benefits of both pharmaceutical and hardware grade CAs when applied in acute care situations. Topics discussed include wound closure as well as the treatment of burns, abrasions, and blisters. Also considered are their chemical properties, toxicities, and potential off-label uses.

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Tensile Strength of Wound Closure with Cyanoacrylate Glue

Cited by 86 publications

References 10 publications

Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair

Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair

Comparison of tensile strength of skin closure by simple interrupted, simple continuous, and staples

Cyanoacrylate Glues for Wilderness and Remote Travel Medical Care

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