Tensile Strength Variation of Binary Tablets Produced by Planetary Ball Milling

Sim, Cholho

doi:10.4333/kps.2008.38.1.001

Journal of Korean Pharmaceutical Sciences

2008

DOI: 10.4333/kps.2008.38.1.001

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Tensile Strength Variation of Binary Tablets Produced by Planetary Ball Milling

Cholho Sim¹

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2013

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Optimization of Process Variables for Grinding of Ibuprofen using Response Surface Methodology

Sim¹

2013

Korean Chemical Engineering Research

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이었다.Abstract − Ibuprofen, non-steroidal anti-inflammatory drugs; NSAIDs, is a highly crystalline substance with the pharmaceutical properties of poor solubility and low bioavailability. The size reduction of ibuprofen is needed to improve the solubility. The objective of this study is to optimize the grinding condition of ibuprofen. Grinding of ibuprofen was carried out using a planetary mill. Grinding parameters were optimized using Box-Behnken experimental design method. The physical characteristics of ground ibuprofen were investigated for the particle size by particle size analyzer, for the crystal size by X-ray diffraction (XRD), and for the tensile strength by tensile/compression tester. The optimum conditions for the milling of ibuprofen were 290 rpm of the revolution number of mill, 24.6 g of the weight of sample, and 10 minutes of grinding time. The measured value of the particle size of ground ibuprofen at these optimum conditions was 13.5 µm. The results showed that the crystal size of ibuprofen was reduced by the planetary milling process. In case the relative density of the tablets formulated of ground ibuprofen was range of 0.85~0.90, the tensile strength of them was range of 12~14 Kg f /cm 2 .

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Optimization of Process Variables for Grinding of Ibuprofen using Response Surface Methodology

Sim¹

2013

Korean Chemical Engineering Research

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Tensile Strength Variation of Binary Tablets Produced by Planetary Ball Milling

Cited by 1 publication

References 38 publications

Optimization of Process Variables for Grinding of Ibuprofen using Response Surface Methodology

Optimization of Process Variables for Grinding of Ibuprofen using Response Surface Methodology

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