Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes
Umida Djakbarova,
Yasaman Madraki,
Emily T. Chan
et al.
Abstract:Integrin-based adhesion complexes are crucial in various cellular processes, including proliferation, differentiation, and motility. While the dynamics of canonical focal adhesion complexes (FAs) have been extensively studied, the regulation and physiological implications of the recently identified clathrin-containing adhesion complexes (CCACs) are still not well understood. In this study, we investigated the spatiotemporal mechanoregulations of FAs and CCACs in a breast cancer model. Employing single-molecule… Show more
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