2024
DOI: 10.1038/s41467-024-49479-4
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TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice

Michał Brouze,
Agnieszka Czarnocka-Cieciura,
Olga Gewartowska
et al.

Abstract: Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating enzymes and substrates in mammals remain unclear. Using knockout and knock-in mouse models, we describe the essential role of four TENT5 poly(A) polymerases in mouse fertility and gametogenesis. TENT5B and TENT5C play crucial yet redundant roles in oogenesis, with the double knockout of both genes leading to oocyte degeneration. Additionally, TENT5B-GFP knock-in females display a gain-of-function infertility effect, wit… Show more

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