Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity

Chao, Guanqun; Wang, Zhaojun; Yang, Chaoyu; Qian, Yanna; Zhang, Shuo

doi:10.1080/1354750x.2020.1849405

Cited by 3 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PAR1 activation and PAR2 inhibition could be used as a suitable means to prevent NSAID enteropathy ( Fornai et al, 2020a ). Teprenone may protect the small bowel against diclofenac-induced damage by inhibiting the expression of PAR1 and PAR2( Chao et al, 2021 ).…”

Section: Factors Involved In the Pathogenesis Of The Nsaid-associated...mentioning

confidence: 99%

NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention

Zhang

Xia

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

With the wide application of non-steroidal anti-inflammatory drugs (NSAIDs), their gastrointestinal side effects are an urgent health burden. There are currently sound preventive measures for upper gastrointestinal injury, however, there is a lack of effective defense against lower gastrointestinal damage. According to a large number of previous animal experiments, a variety of NSAIDs have been demonstrated to induce small intestinal mucosal injury in vivo. This article reviews the descriptive data on the administration dose, administration method, mucosal injury site, and morphological characteristics of inflammatory sites of various NSAIDs. The cells, cytokines, receptors and ligands, pathways, enzyme inhibition, bacteria, enterohepatic circulation, oxidative stress, and other potential pathogenic factors involved in NSAID-associated enteropathy are also reviewed. We point out the limitations of drug modeling at this stage and are also pleased to discover the application prospects of chemically modified NSAIDs, dietary therapy, and many natural products against intestinal mucosal injury.

show abstract

Section: Factors Involved In the Pathogenesis Of The Nsaid-associated...mentioning

confidence: 99%

NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention

Zhang

Xia

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

WeiNaiAn capsule attenuates intestinal mucosal injury and regulates gut microbiome in indomethacin-induced rat

Zheng,

Song,

Huang

et al. 2024

The International Journal of Biochemistry & Cell Biology

View full text Add to dashboard Cite

Development of drug-induced gastrointestinal injury models based on ANN and SVM algorithms and their applications in the field of natural products

Zhang,

Zhou,

Yan

et al. 2024

New J. Chem.

View full text Add to dashboard Cite

show abstract

Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity

Cited by 3 publications

References 34 publications

NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention

NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention

WeiNaiAn capsule attenuates intestinal mucosal injury and regulates gut microbiome in indomethacin-induced rat

Development of drug-induced gastrointestinal injury models based on ANN and SVM algorithms and their applications in the field of natural products

Contact Info

Product

Resources

About