Terahertz Metamaterial Biosensor With Double Resonant Frequencies for Specific Detection of Early-Stage Hepatocellular Carcinoma

Xie, Duan; Li, Dongxia; Hu, Fangrong; Wang, Zhiyou; Zhang, Longhui; Jiang, Mingzhu; Wang, Yuanli

doi:10.1109/jsen.2022.3225344

Cited by 13 publications

(4 citation statements)

References 46 publications

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“…Moreover, the implementation of the proposed design in cancer cell detection results in a very high sensitivity of 2050 GHz/RIU with a FOM of 25.24 RIU -1 for basal type. Further, an average sensitivity of 2000 GHz/RIU has been obtained for other types of cancer which is higher than that reported in the recent literature [9], [11], [20], [22], [31], [53], [63], [64], [65], [66], [67], [68], [69], [70], [71].…”

Section: Discussionmentioning

confidence: 56%

“…The suggested sensor has high sensitivity, S, of 2050 GHz/RIU, high-quality factor, Q, of 55.34, high FOM of 25.24 RIU -1 , and absorption coefficient of 0.94132 in the range from 4.25 THz to 4.75 THz with simple and free-label design. The proposed sensor has higher sensitivity, quality factor, and FOM than those reported in [9], [20], [22], [31], [53], [63], [64], [65], [66], [68], and [70].…”

Section: Introductionmentioning

confidence: 80%

“…The metamaterial sensors can be fabricated with conventional photolithography [5], basic chemical etching [29], and ultra-short laser machining technique [15]. Moreover, the spin coating technique followed by femtosecond laser writing can be utilized for metamaterial fabrication [30], and surface micromachining process [31]. Furthermore, the metallic patches can be thermally deposited on the dielectric layer using chemical vapor deposition (CVD) technique [29].…”

Section: Introductionmentioning

confidence: 99%

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Highly Sensitive Triple-Band THz Metamaterial Biosensor for Cancer Cell Detection

Elhelw,

Ibrahim,

Rashed

et al. 2023

IEEE Photonics J.

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Abstract-Highly sensitive triple-band metamaterial-based biosensor for different cancer cells detection is suggested and numerically analyzed. The reported sensor has a polyimide dielectric layer which is sandwiched between gold bottom plane and top metallic patches. The analyte sample covers the metallic patch where multiple resonances occur with high absorption. The resonance frequencies depend on the optical properties of the analyte sample. Therefore, the proposed sensor can distinguish between different cancer cell types such as skin cancer, blood cancer, and Breast cancer. Full vectorial finite element method is used to study the effects of the geometrical parameters with the aim to maximize the sensor sensitivity. The suggested sensor has high sensitivity of 2050 GHz/RIU (which is much higher than those suggested in the literature) with high quality factor of 55.34 in the frequency range from 4.25 THz to 4.75 THz. Further, the proposed biosensor is a label-free, and easy for fabrication using the state-of-the-art fabrication technologies.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Highly Sensitive Triple-Band THz Metamaterial Biosensor for Cancer Cell Detection

Elhelw,

Ibrahim,

Rashed

et al. 2023

IEEE Photonics J.

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“…Among all these materials, gold nanoparticles (AuNPs) stand out for their excellent biocompatibility, inert nature, minimal toxicity, strong light scattering and/or absorbance, ease of synthesis, and functionalizable surface, which have made them potential candidates for their use in biomedicine applications, including bioimaging, sensing, and therapeutics. 6–10 Among all their properties, it is worth mentioning their unique optical properties caused by their strong interaction with light. The conduction electrons on the metal surface on the nanoparticles undergo a collective oscillation when they are excited by light at specific wavelengths.…”

Section: Introductionmentioning

confidence: 99%

Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy

Rubio-Camacho,

Cuestas-Ayllón,

Torres-Herrero

et al. 2024

RSC Adv.

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Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

Cao,

Jia,

Meng

et al. 2024

Adv Materials Technologies

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Metamaterials (MMs), distinguished by their unique electromagnetic properties, offer significant advantages in the realm of terahertz (THz) biosensing and early disease diagnosis. The intense electric field confined within subwavelength volumes in metallic MMs enhances the interaction between light and analytes. The Q‐factor, sensitivity and figure of merit (FOM) are three critical direct parameters for quantitative evaluation of sensor performance. Researchers are pursuing enhancement of these parameters by optimal design of MMs structures and dimensions as well as proper choice of materials. Recently, dielectric perturbation theory is quantitatively calculated and successfully utilized in the design and optimization of THz MMs sensors. Guided by this theory, this review focuses on the design principle of THz MMs sensors, the various study on how to improve the fundamental parameters of THz MMs sensors, the specific application in biosensing including the functionalization process, and the fabrication of THz MMs sensors. Based on these methods and results, the future development of THz sensors is finally presented in a perspective view.

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Terahertz Metamaterial Biosensor With Double Resonant Frequencies for Specific Detection of Early-Stage Hepatocellular Carcinoma

Cited by 13 publications

References 46 publications

Highly Sensitive Triple-Band THz Metamaterial Biosensor for Cancer Cell Detection

Highly Sensitive Triple-Band THz Metamaterial Biosensor for Cancer Cell Detection

Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy

Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

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