Terahertz time-domain spectroscopy for non-invasive assessment of water content in biological samples

Abstract

We apply terahertz time-domain spectroscopy for the quantitative non-invasive assessment of the water content in biological samples, such as tree leaves and pork muscles. The developed experimental terahertz time-domain spectroscopy system operates both in transmission and reflection modes. The Landau-Looyenga-Lifshitz-based model is used for the calculation of the water concentration within the samples. The results of the water concentration measurements are compared with the results of the gravimetric measurements. The obtained results show that the water content in biological samples can be measured non-invasively, with a high accuracy, utilizing terahertz waves in transmission and reflection modes.

Комплексное Изучение Особенностей Поглощения Сыворотки Крови Крыс С Экспериментальным Раком Печени-=sup=-*-=/Sup=-

“…Релаксационный диэлектрический отклик тканей и растворов характеризуется отсутствием четко выраженных спектральных особенностей в ТHz-диапазоне частот 0.1−3 ТHz. В то же время чувствительность излучения к содержанию воды делает ТHz-спектроскопию и визуализацию привлекательными инструментами меди-цинской диагностики, использующими содержание воды в тканях и ее состояние в качестве информативных признаков для дифференциации [7][8][9].…”

3D Printed Hollow-Core Terahertz Fibers

“…The shorter wavelengths than microwave and millimeter waves allow much greater resolution in imaging, making it suitable for security scanning, imaging, and non-destructive testing [16,17]. Because of the non-ionizing characteristic of terahertz, it can pass through organic tissue without causing damage, and it can be safely applied in biomedical sensing [18,19]. In addition, it is possible to detect many chemicals and biological agents because they exhibit well defined spectral signatures in the terahertz range [20,21].…”

Investigation of Water-free Biotissue-mimicking Phantoms in Terahertz Frequency Range

“…Real biological tissues and organs are not suitable for this purpose because of instability of their properties, in particular, due to presence of water and its evaporation. Since THz radiation is very sensitive to water content [3]- [4], [5], this will significantly affect the measured signal. Therefore, waterfree phantoms are in high demand to substitute real biological tissues and should be developed.…”