Terahertz-wave scattering in tissues: Examining the limits of the applicability of effective-medium theory

Kucheryavenko, A.S.; Dolganova, I.N.; Zhokhov, A.A.; Masalov, V.M.; Musina, G.R.; Tuchin, V.V.; Chernomyrdin, N.V.; Gavdush, A.A.; Il’enkova, D.R.; Garnov, S.V.; Zaytsev, K.I.

doi:10.1103/physrevapplied.20.054050

Cited by 5 publications

(1 citation statement)

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“…Angular or frequency dependent THz systems can readily characterize the scattering in granular materials [ 43 – 46 ]. Given the abundance of components and heterogeneity in biological samples, however, it becomes challenging to separate the contribution of scattering from featureless absorption or measurement noise [ 47 ]. Meanwhile, THz polarization imaging can potentially provide better contrasts in tissue delineation [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Terahertz polarimetric imaging of biological tissue: Monte Carlo modeling of signal contrast mechanisms due to Mie scattering

Xu,

Arbab

2024

Biomed. Opt. Express

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Many promising biomedical applications have been proposed for terahertz (THz) spectroscopy and diagnostic imaging techniques. Polarimetric imaging systems are generally useful for enhancing imaging contrasts, yet the interplay between THz polarization changes and the random discrete structures in biological samples is not well understood. In this work, we performed Monte Carlo simulations of the propagation of polarized THz waves in skin and adipose tissues based on the Mie scattering from intrinsic structures, such as hair follicles or sweat glands. We show that the polarimetric contrasts are distinctly affected by concentration, size and dielectric properties of the scatterers, as well as the frequency and polarization of the incident THz waves. We describe the experimental requirements for observing and extracting these polarimetric signals due to the low energy and small angular spread of the back-scattered THz radiation. We analyzed the spatially integrated Mueller matrices of samples in the normal-incidence back-scattering geometry. We show that the frequency-dependent degree of polarization (DOP) can be used to infer the concentrations and dielectric contents of the scattering structures. Our modeling approach can be used to inform the design of the imaging modalities and the interpretation of the spectroscopic data in future terahertz biomedical imaging applications.

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Section: Introductionmentioning

confidence: 99%

Terahertz polarimetric imaging of biological tissue: Monte Carlo modeling of signal contrast mechanisms due to Mie scattering

Xu,

Arbab

2024

Biomed. Opt. Express

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Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives

Yan,

Cheng,

Yang

et al. 2024

Biotechnology Advances

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Terahertz nanoscopy: Advances, challenges, and the road ahead

Guo,

Bertling,

Donose

et al. 2024

Applied Physics Reviews

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Exploring nanoscale material properties through light-matter interactions is essential to unveil new phenomena and manipulate materials at the atomic level, paving the way for ground-breaking advancements in nanotechnology and materials science. Various elementary excitations and low-energy modes of materials reside in the terahertz (THz) range of the electromagnetic spectrum (0.1–10 THz) and occur over various spatial and temporal scales. However, due to the diffraction limit, a slew of THz studies are restricted to drawing conclusions from the spatially varying THz responses around half of the probing wavelengths, i.e., from tens to a couple of hundred micrometers. To address this fundamental challenge, scanning near-field optical microscopy (SNOM), notably scattering-type SNOM (s-SNOM), combined with THz sources has been employed and is fueling growing interest in this technique across multiple disciplines. This review (1) provides an overview of the system developments of SNOM, (2) evaluates current approaches to understand and quantify light-matter interactions, (3) explores advances in THz SNOM applications, especially studies with THz nano-scale spatial responses employing an s-SNOM, and (4) envisions future challenges and potential development avenues for the practical use of THz s-SNOM.

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Terahertz-wave scattering in tissues: Examining the limits of the applicability of effective-medium theory

Cited by 5 publications

References 99 publications

Terahertz polarimetric imaging of biological tissue: Monte Carlo modeling of signal contrast mechanisms due to Mie scattering

Terahertz polarimetric imaging of biological tissue: Monte Carlo modeling of signal contrast mechanisms due to Mie scattering

Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives

Terahertz nanoscopy: Advances, challenges, and the road ahead

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