Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins

Zhang, Qin; Yang, Lixia; Wang, Kaicheng; Guo, Lianghao; Ning, Hui; Wang, Shaomeng; Gong, Yubin

doi:10.1016/j.isci.2023.107572

Cited by 7 publications

(6 citation statements)

References 51 publications

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“…It is essential to emphasize that we utilized a classical, nonpolarized molecular dynamics simulation method. While this method is efficient and widely employed in the study of terahertz biological effects, − ,,,− it does have its limitations. Notably, it lacks the capability to account for polarization, quantum effects, and other factors.…”

Section: Methodsmentioning

confidence: 99%

“…These two approximate treatments of electromagnetic fields have been widely used in molecular dynamics simulation studies. ,,,,, In our simulations, an electric field of E = E 0 cos(ω t ) was employed to simulate the influence of an electromagnetic field, where E 0 represents the field strength and ω signifies its angular frequency. The strength of the electric field used in this study is 0.4 V/nm, which is on the same order of magnitude as the field strength used in other molecular dynamics simulation studies. ,,− According to English et al, an electric field of this magnitude is reasonable and necessary in molecular dynamics simulations, since the intermolecular localized electric field is usually on the order of V/nm. − The frequencies we focus on in this paper are carbonyl vibrational frequencies in SF. This is because the carbonyl groups in SF are critical to the potassium ion channel function.…”

Section: Methodsmentioning

confidence: 99%

“…Liu and his colleagues demonstrated that the physical field of neural information should be high-frequency electromagnetic fields within the range of terahertz to infrared, with the most probable frequency range being 0.5–100 THz, referred to as generalized terahertz waves . In recent decades, the interaction of terahertz electromagnetic waves with organisms, − cells, − and molecules ,,,− have been extensively studied. An important object among them is the ion channel due to their vital physiological roles previously mentioned.…”

Section: Introductionmentioning

confidence: 99%

“…These two approximate treatments of electromagnetic fields have been widely used in molecular dynamics simulation studies. 8,9,14,27,31,52 In our simulations, an electric field of E = E 0 cos(ωt) was employed to simulate the influence of an electromagnetic field, where E 0 represents the field strength and ω signifies its angular frequency. The strength of the electric field used in this study is 0.4 V/nm, which is on the same order of magnitude as the field strength used in other molecular dynamics simulation studies.…”

Section: Introductionmentioning

confidence: 99%

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Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Zhao,

Ding,

Wang

et al. 2024

ACS Omega

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Potassium ion channels are the structural basis for excitation transmission, heartbeat, and other biological processes. The selectivity filter is a critical structural component of potassium ion channels, whose structure is crucial to realizing their function. As biomolecules vibrate and rotate at frequencies in the terahertz band, potassium ion channels are sensitive to terahertz waves. Therefore, it is worthwhile to investigate how the terahertz wave influences the selectivity filter of the potassium channels. In this study, we investigate the structure of the selectivity filter of Kv1.2 potassium ion channels using molecular dynamics simulations. The effect of an electric field on the channel has been examined at four different resonant frequencies of the carbonyl group in SF: 36.75 37.06, 37.68, and 38.2 THz. As indicated by the results, 376GLY appears to be the critical residue in the selectivity filter of the Kv1.2 channel. Its dihedral angle torsion is detrimental to the channel structural stability and the transmembrane movement of potassium ions. 36.75 THz is the resonance frequency of the carbonyl group of 376GLY. Among all four frequencies explored, the applied terahertz electric field of this frequency has the most significant impact on the channel structure, negatively impacting the channel stability and reducing the ion permeability by 20.2% compared to the absence of fields. In this study, we simulate that terahertz waves in the mid-infrared frequency region can significantly alter the structure and function of potassium ion channels and that the effects of terahertz waves differ greatly based on frequency.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Zhao,

Ding,

Wang

et al. 2024

ACS Omega

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“…It is known that hydrogen bonds (H-bond) exhibit characteristic vibration in the terahertz frequency band, and water confined in the nanopores exhibits a distinct H-bond network from bulk water. 48–54 These facts denote a targeted interaction between terahertz waves and water molecules within the MOF membrane. Therefore, we are curious whether terahertz waves can effectively manipulate the dynamic characteristics of water within MOFs, potentially leading to significant improvements in permeability.…”

Section: Introductionmentioning

confidence: 99%

Enhanced water permeation through the terahertz-induced phase and diffusion transition in metal–organic framework membranes

Zhu,

Wang,

Yan

et al. 2024

Phys. Chem. Chem. Phys.

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Nanotechnology-Enabled PCR with Tunable Energy Dynamics

Zhao,

Peng,

et al. 2024

JACS Au

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This Perspective elucidates the transformative impacts of advanced nanotechnology and dynamic energy systems on the polymer chain reaction (PCR), a cornerstone technique in biomedical research and diagnostic applications. Since its invention, the optimization of PCR—specifically its efficiency, specificity, cycling rate, and detection sensitivity—has been a focal point of scientific exploration. Our analysis spans the modulation of PCR from both material and energetic perspectives, emphasizing the intricate interplay between PCR components and externally added entities such as molecules, nanoparticles (NPs), and optical microcavities. We begin with a foundational overview of PCR, detailing the basic principles of PCR modulation through molecular additives to highlight material-level interactions. Then, we delve into how NPs, with their diverse material and surface properties, influence PCR through interface interactions and hydrothermal conduction, drawing parallels to molecular behaviors. Additionally, this Perspective ventures into the energetic regulation of PCR, examining the roles of electromagnetic radiation and optical resonators. We underscore the advanced capabilities of optical technologies in PCR regulation, characterized by their ultrafast, residue-free, and noninvasive nature, alongside label-free detection methods. Notably, optical resonators present a pioneering approach to control PCR processes even in the absence of light, targeting the often-overlooked water component in PCR. By integrating discussions on photocaging and vibrational strong coupling, this review presents innovative methods for the precise regulation of PCR processes, envisioning a new era of PCR technology that enhances both research and clinical diagnostics. The synergy between nanotechnological enhancements and energy dynamics not only enriches our understanding of PCR but also opens new avenues for developing rapid, accurate, and efficient PCR systems. We hope that this Perspective will inspire further innovations in PCR technology and guide the development of next-generation clinical detection instruments.

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Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins

Cited by 7 publications

References 51 publications

Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Enhanced water permeation through the terahertz-induced phase and diffusion transition in metal–organic framework membranes

Nanotechnology-Enabled PCR with Tunable Energy Dynamics

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