Terapia con lactato sódico hipertónico en trauma cráneo-encefálico: ¿se convertirá en la mejor alternativa de manejo?

Betancur-Calderón, Juan Martín; Veronesi-Zuluaga, Luz Amaya; Castaño-Tobón, Héctor Fabio

doi:10.1016/j.rca.2017.08.009

Cited by 1 publication

(4 citation statements)

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“…The results obtained showed that the sodium lactate reduced IH episodes compared to control group (p <0.05); this suggests that sodium lactate can be used as an alternative treatment for preventing post IH traumatic brain injury. Moreover, in patients receiving sodium lactate, better urine output and an optimal fluid balance she was found (4,31).…”

Section: Sodium Lactate Vs Mannitolmentioning

confidence: 99%

“…As late consequences, at this stage an imbalance of the neurotransmitter regulation, axonal damage and cell death occurs (30). In the secondary phase will be altered cerebral autoregulation mechanisms; generating power failures, which are to be supplied momentarily by increased glycolysis and oxidative phosphorylation; out of ATP stores, anaerobic metabolism begins until this process is unsatisfactory (30,31).…”

Section: Sodium Lactatementioning

confidence: 99%

“…There is a theory that suggests that astrocytes use the process of glycolysis to lactate production; once said lactate enters neuronal cells, this is transformed into pyruvate by the action of lactate dehydrogenase, and thus involved in oxidative metabolism and energy generating (27,32). Under physiological conditions, lactate contributes 8% of the energy required by the brain; however, in cases where there is brain damage, and decreased levels of glucose, lactate can contribute over 60% (31). For this reason, sodium lactate has been a very promising method in controlling the IH in cases of severe brain trauma, requiring more research that yield firm conclusions about the use of this solution with respect to the other, analyzing their effects beneficial and adverse effects.…”

Section: Sodium Lactatementioning

confidence: 99%

“…For this reason, sodium lactate has been a very promising method in controlling the IH in cases of severe brain trauma, requiring more research that yield firm conclusions about the use of this solution with respect to the other, analyzing their effects beneficial and adverse effects. Sodium lactate acts primarily by decreasing the blood viscosity by increasing plasma volume, resulting in an increased blood flow and brain tissue oxygenation (31). Once increased perfusion of the brain tissue, vasoconstriction occurs reflects which contributes to decrease ICP by limiting blood supply to the brain.…”

Section: Sodium Lactatementioning

confidence: 99%

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Osmotherapy in patients with severe brain trauma

Reina-Rivero,

Gaitán-Herrera,

García-García

et al. 2022

roneuro

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Traumatic brain injury is still a major cause of mortality and morbidity in the world and is considered a public health problem that needs to be well attended to. Cerebral oedema due to brain injury compromises the delivery of essential nutrients and alters normal intracranial pressure, whose increase has been shown to be strongly associated with poor neurological outcomes and mortality for patients with head trauma. Intravenous fluids are a fundamental component of trauma care and fluid management influences patient outcomes. Thanks to advances in the research of osmotic agents, mortality has been reduced and there has been greater control in intracranial pressure. The osmotic agents most used for the control of intracranial pressure in patients who have suffered severe brain trauma are mannitol and hypertonic saline. However, in recent years have been studying the benefits that sodium lactate can generate in these cases. It has been found that sodium lactate has generated a greater decrease in intracranial pressure values and lower mortality rates with respect to mannitol and hypertonic saline. This still has been disputed as an application of mannitol, hypertonic saline or sodium lactate for treating patients who have suffered some head trauma. This review aims to show the advantages, disadvantages and recommendations of the different hyperosmolar solutions mentioned previously based on current evidence.

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Section: Sodium Lactate Vs Mannitolmentioning

confidence: 99%