Terapia de reperfusión en infarto agudo al miocardio: Comparación entre trombolisis endovenosa y angioplastía coronaria

Ugalde, Héctor; Ugalde, Diego; Muñoz, Macarena

doi:10.4067/s0034-98872011001100002

Cited by 2 publications

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“…Más recientemente, el 2010, se comunicó la comparación de un grupo mayor de pacientes, aportados por los registros GEMI y RENAC, con resultados muy semejantes 4 . A estas estimaciones de mortalidad por infarto en Chile, se agregan los datos del estudio publicado en esta edición por Ugalde et al, datos de un solo centro en Santiago, comunicando mortalidad intrahospitalaria de 11,2% para trombolisis, y de 2% para angioplastía 5 . Estas últimas cifras resultan más difíciles de aceptar como una estimación válida de la realidad nacional, por constituir un grupo menos numeroso de pacientes y por haber excluido los pacientes más graves, sin que los autores revelen el número de tales exclusiones, ni el tratamiento preferente de reperfusión en ese grupo.…”

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Mortalidad por infarto del miocardio en Chile: Trombolíticos o angioplastía

2011

Rev. méd. Chile

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Mortalidad por infarto del miocardio en Chile: Trombolíticos o angioplastía

2011

Rev. méd. Chile

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The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

Gonca

2013

Current Therapeutic Research

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Background5-Lipoxygenase is an enzyme involved in the synthesis of leukotriene eicosanoids from arachidonic acid. The therapeutic potential of zileuton, an inhibitor of 5-lipoxygenase, and montelukast, a cysteinyl leukotriene receptor antagonist, for the treatment of ischemia/reperfusion (I/R) injury of the heart has been proposed in a few studies. However, the effects of zileuton and montelukast on I/R-induced arrhythmias have not been determined.ObjectiveWe assessed the possible protective effects of zileuton and montelukast against I/R-induced arrhythmias.MethodsForty-five male Wistar albino rats were divided into 5 groups, each containing 9 rats. Group 1: control, Groups 2 and 3: rats treated with montelukast (10 and 30 mg/kg IP); and Groups 4 and 5: rats treated with zileuton (1 and 3 mg/kg IV) 15 minutes before the induction of ischemia. Ischemia and reperfusion were induced by occluding the left main coronary artery of anesthetized rats for 6 minutes followed by reopening the artery for 6 minutes.ResultsBoth doses of zileuton decreased the mean [SE] arrhythmia score (zileuton 1 mg/kg: 1.4 [0.8]; zileuton 3 mg/kg: 1.3 [0.5] vs control: 2.9 [0.3]; P < 0.05), the duration of ventricular tachycardia, and the total length of arrhythmias, but montelukast was not effective to decrease the ventricular arrhythmias during the 6 minutes of reperfusion.ConclusionsThe results indicate for the first time that zileuton exerts an antiarrhythmic effect at different doses and that montelukast is not effective against I/R-induced arrhythmias. These results indicate that zileuton may be a candidate for drug treatment of I/R-induced arrhythmias.

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Terapia de reperfusión en infarto agudo al miocardio: Comparación entre trombolisis endovenosa y angioplastía coronaria

Abstract: (Rev Med Chile 2011; 139: 1396-1402.

Cited by 2 publications

References 28 publications

Mortalidad por infarto del miocardio en Chile: Trombolíticos o angioplastía

Mortalidad por infarto del miocardio en Chile: Trombolíticos o angioplastía

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

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