2009
DOI: 10.1007/s12325-009-0011-z
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Teratogenesis associated with antibipolar agents

Abstract: Well-characterized risks are associated with valproate, carbamazepine, lamotrigine, and lithium. The risks associated with psychotropic drug use need to be understood in the context of significant rates of relapse and associated morbidity when discontinuing bipolar treatment during pregnancy.

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Cited by 49 publications
(38 citation statements)
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“…However, the vaccination of laying hens does not completely guarantee the control of internal egg contamination by Salmonella in entire chicken flocks. Several reports showed the presence of Salmonella inside the reproductive organs from vaccinated laying hens that could enter the internal egg [34,35].…”
Section: Preventive Methods For Minimizing Contaminationmentioning
confidence: 99%
“…However, the vaccination of laying hens does not completely guarantee the control of internal egg contamination by Salmonella in entire chicken flocks. Several reports showed the presence of Salmonella inside the reproductive organs from vaccinated laying hens that could enter the internal egg [34,35].…”
Section: Preventive Methods For Minimizing Contaminationmentioning
confidence: 99%
“…Assessment of sometimes severe teratogenic or other adverse developmental effects associated with drug exposures during pregnancy is complicated by their generally low incidence, coupled with a substantial risk of spontaneous or unexplained fetal malformations, on the order of 3-5% among children born of mothers with no known exposures to potential teratogenic foreign (xenobiotic) substances [ 252 ] . Until recently, there appears to have been an unbalanced focus on risk of fetal malformations in association with use of psychotropic medicines during pregnancy, and marked regional differences in attitudes about such risks continue.…”
Section: Pregnancymentioning
confidence: 99%
“…As a group, they carry elevated risks of a range of fetal malformations [ 252,329,345 ] . Valproate is especially dangerous, with risks of malformations of derivatives of the fetal neural crest, including spina bi fi da, at rates of several percent of exposed women.…”
Section: Pregnancymentioning
confidence: 99%
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“…Valproate has been associated with teratogenicity (Nguyen 2009) and weight gain, as well as polycystic ovarian syndrome, although the latter association is controversial (Joshi 2008).…”
Section: Mood Stabilisersmentioning
confidence: 99%