Contaminated shell egg is one of the key Salmonella infection routes for human, causing food-borne illnesses. Multiple salmonellosis infections due to egg contamination still occur in developed countries even though preventive methods, such as vaccination or washing followed by rinsing process, are carried out following certified national standards. Recent outbreaks indicated that current strategies for Salmonella control need to be optimized to further minimize contamination of commercial eggs. Therefore, there is a critical need to develop more sensitive and rapid Salmonella detection methods. In this review, we address (i) egg production; (ii) preventive methods that minimize contamination; (iii) mechanisms of Salmonella contamination; (iv) Salmonella detection methods.