Teratogenesis of acetazolamide in the CBA/J and SWV strains of mice. II. Genetic control of the teratogenic response

Abstract

Three independently segregating loci appear to control the difference in response of CBA and SWV mouse embryos to the ectrodactyly-inducing effect of acetazolamide. Response of the CBA embryo appears to depend on recessive genes for sensitivity being present in the homozygous condition at all 3 loci, and resistance to be conferred by the presence of a dominant allele at any one of the 3 loci. The genetic variability for the ectrodactyly response of the mouse is discussed in the light of the reported physiological factors necessary for acetazolamide-induced ectrodactyly in the rat.

Variable patterns of malformation in the mouse fetal hydantoin syndrome

“…In light of this and other animal studies, it is becoming increasingly obvious that the genotype plays an important role in determining teratogenic sensitivity for both single and multiple malformations [Biddle, 1975[Biddle, , 1977Biddle and Fraser 1976;Chernoff, 19771. With single malformations following acute exposure to a teratogen, genetic differences in susceptibility concern only one or a few organ systems.…”

Statistical analysis of litter experiments in teratology

“…Specifically, the samples must be approximately normally distributed and possess approximately equal variances. Commonly used transformations include the square root, z .. (Biddle, 1975),…”

Acetazolamide teratology and its association with carbonic anhydrase inhibition in the mouse

“…Towards this end we have employed two strains of mice that exhibit a difference in teratologic sensitivity to acetazolamide. Biddle [12][13][14] reported that the SWV strain of mouse is highly resistant to the teratologic effects of acetazolamide. Using reciprocal crosses between resistant SWV and sensitive CBA/J strains, Biddle demonstrated that teratologic resistance was genetically dominant.…”