Teratogenesis of calcium valproate in rats

Ong, Lina L.; Schardein, James L.; Petrere, Judith A.; Sakowski, Raymond; Jordan, Hollis; Humphrey, Ronald R.; Fitzgerald, James E.; Iglesia, Felix A. de la

doi:10.1016/s0272-0590(83)80067-0

Cited by 66 publications

(20 citation statements)

References 15 publications

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“…Neural, renal, cardiac, urogenital, and musculoskeletal abnormalities have been found in rabbits (Petrere et al, 1986), rodents (Kao et al, 1981;Ong et al, 1983), and nonhuman primates (Mast et al, 1986). In humans, in utero exposure to valproic acid has been associated with neural, craniofacial, cardiovascular, and musculoskeletal defects (Table 3) (Jager-Roman et al, 1986;Winter, 1987;Kozma, 2001).…”

Section: B Antiepileptic Drugsmentioning

confidence: 99%

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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Section: B Antiepileptic Drugsmentioning

confidence: 99%

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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“…When a conception had taken place, the female was placed in a cage with a drinking bottle containing either water (controls), or a water solution of valproic acid (Ergenyl A ) at a concentration of 3 mg/ml which will represent a daily dose of about 125 mg. This dose roughly corresponds to the teratogenic dose for sodium valproate described for instance by Ong et al (1983). One series was also made with a doubled dose.…”

Section: Methodsmentioning

confidence: 95%

Valproic Acid is Known to Cause Hypospadias in Man but does not Reduce Anogenital Distance or Causes Hypospadias in Rats

Källén

2004

Pharmacol Toxicol

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“…In addition, from the first day of gestation, folic acid (Pteryoglutamic acid vit M, Sigma F 8798) was administered via an orogastric tube at a dose of 400 µ /kg. One hour before the injection of VPA and FA, vitamin E (a-Tocopherol, Sigma T-3251) was administered by gastric intubation to dams at a dose of 250 mg/kg (Vorhees;Deeb et al;Berry et al, 1999;Ehlers et al, 1996;Ong et al, 1983).…”

Section: Experimental Protocolmentioning

confidence: 99%

The Effects of Valproic Acid on Sciatic Nerve of Fetal Rats and Protective Effects of Folic Acid and Vitamin E

et al. 2009

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SUMMARY:We aimed to investigate the potential harmful effects of maternal valproic acid (VPA) on fetal sciatic nerve, and the protective effects of vitamin E (Vit E) and folic acid (FA) on fetal rats. Valproic acid (400mg/kg), folic acid (400mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days 8-10. All fetuses were collected on gestation day 20. With thin sections of biopsies, sciatic nerve of fetuses were stained with uranyl acetat and were examined under transmission electron microscope. The fetuses (n:36) were divided into five groups: control, vpa, vpa+fa, vpa+vit e and vpa+fa+vit e groups. In each group; drug procedure, surgical procedure and histological methods were performed. Later, weights and lengths of fetuses in each group were compared and analyzed by One-Way Anova test. Administration of single doses of valproic acid (400 mg/kg) resulted in weight and length loss between control and vpa group. However, length and weight differences between the other groups were not significant. The histopathological findings of control group was normal. In vpa group, it showed extensive degenerative changes especially in myelin coat. In addition, most prominent finding in this group was condensation of collagen fibers in extensively demyelinated samples, while moderately effected areas were relatively normal. Both vpa+fa and vpa+ vit e groups exhibited similar ultrastructural changes, reflecting minimal to moderate degenerative changes. In vpa+fa+vit e group had almost the normal structure. Administration of single doses of valproic acid (400 mg/kg) resulted in a deteriorative effect on sciatic nerve at ultrastructural level. Administration of FA and Vit E had a protective effect to prevent the degenerative changes to a certain degree. Combination of FA and Vit E together following VPA administration had a more potent protective effect. The objective of the present study is to analyze histopathologic changes which may occur in a high risk experimental model after the administration of valproic acid. In addition, protective roles of the administration of folic acid and vitamin E are assessed.

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Teratogenesis of calcium valproate in rats

Cited by 66 publications

References 15 publications

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Valproic Acid is Known to Cause Hypospadias in Man but does not Reduce Anogenital Distance or Causes Hypospadias in Rats

The Effects of Valproic Acid on Sciatic Nerve of Fetal Rats and Protective Effects of Folic Acid and Vitamin E

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