Teratogenic assessment of three methylated hydrazine derivatives in the rat

Keller, William C.; Olson, Carl; Back, Kenneth C.; Gaworski, Charles L.

doi:10.1080/15287398409530486

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…MH significantly increased the incidence of lung tumors in Swiss mice (Toth, 1972). Nevertheless, the US Environmental Protection Agency has not classified MH for carcinogenicity (Reddy et al, 2010) and teratogenicity (Keller et al, 1984;Slanina et al, 1993).…”

Section: Patocka Et Al: Natural Fungal Toxinsmentioning

confidence: 99%

Gyromitrin, Mushroom Toxin of Gyromitra Spp.

Patočka¹,

Pita²,

Kuča³

2012

MMSL

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Gyromitra esculenta (Persoon ex Fries) mushrooms have been responsible for severe intoxications and even deaths. Clinical data are characterized primarily by vomiting and diarrhea and after a while by jaundice, convulsions and coma. Other Gyromitra species which may be of concern are G. fastigiata and G. gigas; nevertheless, recent advances in chromatography, biochemistry and toxicology have established that other species within the Ascomycetes may also prove toxic. Their toxins, mainly gyromitrin (N-methyl-N-formyl-N-acetyl-hydrazone) and their higher homologues are converted in the milieu of human stomach into N-methyl-N-formylhydrazine (MFH), then into N-methylhydrazine (MH). The toxicity of these latter chemicals, which are mainly hepatotoxic and even carcinogenic, has been established through in vivo and in vitro experiments with cell cultures and biochemical systems. Considering the chemical structure and the reactivity of these natural compounds, chemical and biochemical mechanisms are defined in order to explain their intrinsic biological activity. These findings imply that consumption of G. esculenta could present a carcinogenic as well as an acutely toxic health hazard.

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Section: Patocka Et Al: Natural Fungal Toxinsmentioning

confidence: 99%

Gyromitrin, Mushroom Toxin of Gyromitra Spp.

Patočka¹,

Pita²,

Kuča³

2012

MMSL

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“…The results of a teratogenicity assessment of 1,2-dimethylhydrazine and 1,1-dimethylhydrazine in rats were reported by Keller et al (1984) (Tables 40 and 41). In this study, groups of 14-18 pregnant Fischer 344 (F344) rats were given 1,1-dimethylhydrazine in saline (10, 30, or 60 milligrams per kilogram per day (mg/ kg/ d) intraperitoneally (i.p.))…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 99%

“…Source: Keller et al, 1984. fetuses, live fetuses, and resorptions. Fetuses were examined for evidence of terata.…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 99%

“…g Unfused ossi cation centers of vertebrae and sternebrae. Source: Keller et al, 1984. effects were observed at exposures that also induced maternal toxicity (bodyweight loss). Brusick and Matheson (1976) reported that 1,1-dimethylhydrazine failed to increase reversions in Salmonella typhimurium or Saccharomyces cerevisiae gene mutation assays with or without metabolic activat ion.…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 99%

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Dimethylhydrazine

2001

Inhalation Toxicology

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Alkylpyridines and Miscellaneous Organic Nitrogen Compounds

Peterson

2023

Patty's Toxicology

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This chapter provides a broad overview of topics related to the occupational use and exposure to a variety of miscellaneous nitrogen‐containing compounds. Topics addressed include chemical/physical properties, uses, exposure assessment, and toxic effects, as well as standards, regulations, and guidelines for exposure. Some of the chemicals and classes represented in this chapter include pyridine, alkylpyridines, vinylpyridines, aminopyridines, aminopicolines, pyridinethione compounds (pyrithiones), nicotine, the substituted uracils, quaternary herbicides, s ‐triazine herbicides, propazine, cyanazine, ametryn, prometryn, simazine, hexazinone, azides, and hydrazine and its derivatives.

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Teratogenic assessment of three methylated hydrazine derivatives in the rat

Cited by 7 publications

References 3 publications

Gyromitrin, Mushroom Toxin of Gyromitra Spp.

Gyromitrin, Mushroom Toxin of Gyromitra Spp.

Dimethylhydrazine

Alkylpyridines and Miscellaneous Organic Nitrogen Compounds

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