Teratogenic effects of carboplatin, an oncostatic drug, administered during the early organogenetic period in rats.

Kai, Shuichi; Kohmura, Hisashi; Ishikawa, Katsumi; Makihara, Yukako; Ohta, Satoshi; Kawano, Shigeo; Takahashi, Norimitsu

doi:10.2131/jts.14.115

Cited by 25 publications

(10 citation statements)

References 30 publications

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“…35,36 Moreover, a transplacental transfer of cisplatin in mice has already been described. 37 Worthy of note, Lanowska et al 14 correlated in vivo cisplatin concentration in the fetomaternal compartment and in breast milk with child development.…”

Section: Resultsmentioning

confidence: 99%

Platinum Derivatives During Pregnancy in Cervical Cancer

Zagouri

Sergentanis

Chrysikos

et al. 2013

Obstetrics &Amp; Gynecology

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Section: Resultsmentioning

confidence: 99%

Platinum Derivatives During Pregnancy in Cervical Cancer

Zagouri

Sergentanis

Chrysikos

et al. 2013

Obstetrics &Amp; Gynecology

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“…In these rodents no teratogenic effects were detected when carboplatin was administered from day 7 to 17 of gestation. However, treatment in early pregnancy during organogenisis induced intra-uterine death and congenital malformations like gastroschisis, dilatation of cerebral ventricles, or skeletal malformations [42][43][44][45]. Therefore, cytotoxic treatment should be reserved to the later stages of pregnancy and abortion has to be considered in patients scheduled for chemotherapy during organogensis.…”

Section: Chemotherapy During Pregnancymentioning

confidence: 99%

Adnexal Masses in Pregnancy

et al. 2003

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With the widespread use of routine abdominal ultrasound examination during pregnancy, adnexal masses are observed with increasing frequency. Most patients are clinically asymptomatic at the time of presentation, and most of the adnexal masses detected during early pregnancy disappear during the first 16 weeks of pregnancy. Ovarian tumors are estimated to occur in about 1 in 1,000 pregnancies and of these 3% are malignant. Here we present an overview about frequency, diagnostic procedures and pathological characteristics of these ovarian tumors. Moreover, current modalities for treatment during pregnancy are summarized. Surgical treatment of the adnexal masses has to be performed with adequate staging and debulking equal to the treatment of non-pregnant women. However, whereas during organogenesis abortion has to be considered prior to chemotherapy, later in pregnancy surgical debulking as complete as possible, followed by taxol-platinum chemotherapy is indicated. If the fetus is not viable at the time of primary surgery, neoadjuvant chemotherapy and complementation of surgery after delivery of the baby should be performed. It should be stressed that chemotherapy for ovarian cancer applied during pregnancy appears to be safe. However, no studies have evaluated the long-term consequences for children exposed to intra-uterine chemotherapy. Aspiration of cysts should be avoided, as the correlation between the histological evaluation of an ovarian malignancy and the cytological evaluation of aspirates is poor. Moreover, spillage of malignant cysts is hazardous for the patient.

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“…Although there is a risk of congenital malformations as a result of in utero fetal exposure during the first trimester (7.5–17% with single agent to 25% with combination chemotherapy), platinum administration has been reported to be relatively safe in the second and third trimesters with slightly increased risks of low birth weight and growth restriction, preterm birth or intra‐uterine death . However, although the neonatal outcomes have been reported as good (11) in this and other cancers, platinum derivatives have previously been shown to cross the placenta in mice and to demonstrate mutagenic and teratogenic effects in animals . Lanowaska et al .…”

Section: Discussionmentioning

confidence: 99%