Teratogenic Effects of Thalidomide in the Sprague Dawley Rat

Evaluation of the developmental toxicity of lenalidomide in rabbits

“…Since the original descriptions of limb malformation and other abnormalities associated with thalidomide in the 1960s, as summarized by Schardein (1985) and Shepard (1989), the teratogenic effects of thalidomide have been studied in mice, rats, monkeys, and rabbits (King and Kendrick, 1962;Fratta et al, 1965;Nudleman and Travill, 1971;Parkhie and Webb, 1983). In view of differences in the developmental effects of thalidomide in various species and the fact that exposure to thalidomide produces limb malformations in rabbit fetuses, among other findings, the NZW rabbit is traditionally considered to be an appropriate model for evaluating the developmental toxicity of thalidomide in humans (Fratta et al, 1965;Schardein, 1985).…”

The History and Implications of Testing Thalidomide on Animals

“…Historically, writers and scientists, for example Ringach in 2010 [24], have cited various combinations of studies, including those by by McColl [123], Dipaolo and others [107,[124][125][126] in support of their position that rats suffered from humanlike defects when thalidomide was administered chronically. This is, in fact, not what these studies revealed and hence is worthy of further consideration over the next several paragraphs.…”

“…King and Kendrick [124] studied rat fetuses after administering thalidomide at various doses and stages during development over a 2½ year period. They noted numerous gross malformations, occurring in 14.6% of the fetuses, and an increase in reabsorption but no phocomelia.…”

Recherche de I’effet tératogène de la 2-diéthylaminopropiophénone

“…Récemment la thalidomide a été étudiée par de nombreux pharmacologistes ; chez le rat son effet a été discuté (7,22,29…”