TERATOLOGICAL STUDY OF CEFODIZIME SODIUM IN MICE : Intravenous Administration during Period of Organogenesis

Food Additives and Contaminants

1997

The natural colour additive, lac dye, was given in the diet to provide levels of 0 (control), 0.15, 0.30, and 0.60%, from 5 weeks of age in the F0 generation to 9 weeks of age in the F1 generation in mice, and selected reproductive and neurobehavioural parameters were measured. There were no adverse effects of lac dye on either litter size or litter weight and sex ratio at birth. The average body weight of offspring during the late lactation period was significantly increased in treatment groups of each sex. In the neurobehavioural parameters, swimming head angle was significantly affected in male offspring during the early lactation period in a dose-related manner, and olfactory orientation was significantly accelerated in female offspring in a dose-related manner. The dose levels of lac dye in the present study produced few adverse effects in reproductive and neurobehavioural parameters in mice.

mentioning

confidence: 99%

“…The water temperature was maintained at 20 ± 1 °C. The time taken and number of errors were measured from the start to finish for a maximum of 120 s. If the time taken was greater than 120 s, it was recorded as 120 s (Kitatani et al 1988). ment group.…”

mentioning

confidence: 99%

Reproductive and neurobehavioural effects of lac dye administered in the diet to mice

Food Additives and Contaminants

1997

“…The measurement parameters were: number of movements, movement time (s), number of horizontal activities, total distance (cm), number of vertical activities, vertical time (s), number of turnings, average distance (cm), average speed (cm/s), and number of defecations. The animals each performed one trial a day for 3 days in a multiple water T-maze of Biel's type adapted for mice at 7 weeks of age in the F1 generation (Biel, 1940;Kitatani et al, 1988). The water temperature was maintained at 20 ± 1 °C.…”

Section: Neurobehavioral Proceduresmentioning

confidence: 99%

Reproductive and Neurobehavioral Effects of Chlorpropham Administered to Mice in the Diet

1997

Toxicol Ind Health

Chlorpropham was given in the diet to provide levels of 0(control), 0.15, 0.30, and 0.60%, from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were no adverse effects of chlorpropham on either litter size or litter weight and sex ratio at birth. The average body weight of offspring was significantly affected in the low-dose group of each sex and in the high-dose group of females, and was increased in the middle-dose group of males during the lactation period. In neurobehavioral parameters, surface righting at postnatal day (PND) 7 was significantly affected in male offspring in a dose-related manner. Swimming head angle at PND 4 was significantly restrained in male offspring in a dose-related manner, and olfactory orientation at PND 14 was significantly depressed in female offspring in a dose-related manner. The dose levels of chlorpropham in the present study produced some adverse effects in reproductive and neurobehavioral parameters in mice.

“…The animals performed each one of the trials for three days in a multiple water T-maze of Biel's type adapted for mice at seven weeks of age of the F1 generation (Biel, 1940;Kitatani et al, 1988). The water temperature was maintained at 20 ± 1°C.…”

Section: Experimental Designmentioning

confidence: 99%

“…The time taken and number of errors were measured from start to finish for a maximum of 120 sec. If the time taken was greater than 120 sec, it was recorded as 120 sec (Kitatani et al, 1988). Statistical Analysis Food intake, litter size, litter weight, and body weight were assessed with the Bonferroni's s multiple comparison test after the analysis of variance (ANOVA) or the Kruskal-Wallis test.…”

Section: Experimental Designmentioning

confidence: 99%

Reproductive and Neurobehavioral Effects of Cochineal Administered To Mice in the Diet

1995

Toxicol Ind Health

Mice were given the natural color additive cochineal in their food to provide dietary levels of 0 (control), 0.5, 1.0, and 2.0%, from five weeks of age in the F0 generation to nine weeks of age in the F1 generation, and selected reproductive and behavioral parameters were measured. Cochineal had few adverse effects on litter size, weight, or sex ratio. The average body weight of offspring during the lactation period was significantly decreased in higher-dosed groups of each sex. With regard to the neurobehavioral parameters, surface righting at postnatal day (PND) four was significantly affected in male offspring during the lactation period. Several parameters of movement activity in females were significantly different from controls at eight weeks of age in the F0 generation and at three weeks of age in the F1 generation. Multiple water T-maze performance of females was affected in treatment groups in the second trial at seven weeks of age in the F1 generation. The dose levels of cochineal in this study produced some adverse effects in reproductive and neurobehavioral parameters in mice.