Terbinafine induced pancreatitis in a healthy young adult male

Abstract

Dear Editor, Terbinafine (Lamasil™) is an oral antifungal approved for the treatment of dermatophyte-induced onychomycosis in adults. 1 Terbinafine acts as a non-competitive inhibitor of squalene epoxidase, inhibiting fungal membrane production, and causing cell death secondary to intracellular squalene accumulation. 1 Adverse events related to Terbinafine are well documented, occurring in more than one in 10 patients. 2 Most adverse events are mild and self-limited examples include headaches, gastrointestinal symptoms, and rash. 1 Severe adverse events are less common, and include toxic epidermal necrolysis, cutaneous or systemic lupus erythematosus, and fulminant hepatitis among others. 1 Hilliard T. Brydges and Ogechukwu C. Onuh contributed equally to the production of this manuscript.