2015
DOI: 10.4103/0253-7613.169574
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Terbinafine induced pityriasis rosea-like eruption

Abstract: Terbinafine is an allylamine antifungal agent which is widely used for the treatment of fungal infections. Cutaneous side effects have been reported in 2% of the patients on terbinafine therapy with many morphological patterns. We report a case of terbinafine induced pityriasis rosea, a very rare side effect of terbinafine. This report emphasizes the importance of counseling the patient to report immediately in the event of a cutaneous eruption.

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Cited by 19 publications
(14 citation statements)
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“…For example, acrylamide antimicrobials are antifungal drugs , aminoglycosides are especially effective against infections with members of the Enterobacteriaceae and Staphylococcus aureus and sulfonamides are broad‐spectrum antimicrobials . A large number of reports on clinical adverse reactions indicate that acrylamides, represented by terbinafine hydrochloride, can cause serious cutaneous side effects, such as pityriasis rosea . Aminoglycosides, such as sisomicin hydrochloride can lead to systemic contact dermatitis , while sulfa drugs, such as sulfamethoxazole, have been shown to cause hypersensitivity reactions in the treatment of children with brucellosis .…”
Section: Introductionmentioning
confidence: 99%
“…For example, acrylamide antimicrobials are antifungal drugs , aminoglycosides are especially effective against infections with members of the Enterobacteriaceae and Staphylococcus aureus and sulfonamides are broad‐spectrum antimicrobials . A large number of reports on clinical adverse reactions indicate that acrylamides, represented by terbinafine hydrochloride, can cause serious cutaneous side effects, such as pityriasis rosea . Aminoglycosides, such as sisomicin hydrochloride can lead to systemic contact dermatitis , while sulfa drugs, such as sulfamethoxazole, have been shown to cause hypersensitivity reactions in the treatment of children with brucellosis .…”
Section: Introductionmentioning
confidence: 99%
“…[2][3][4] Nevertheless, there were only three reported cases of pityriasis rosea-like eruption associated with terbinafine. 1 The literature review suggests that the latency periods between the administration of terbinafine and the exacerbation or de novo appearance of psoriasis is categorized as "short" (less than 4 weeks), as in our case. 3 Terbinafine-induced AGEP has been reported in psoriatic patients.…”
mentioning
confidence: 67%
“…reported in 2% of patients treated with terbinafine. 1 We report an atypical case of terbinafine-induced pityriasis rosea-like eruption followed by induced annular pustular psoriasis.…”
mentioning
confidence: 93%
“… 2 Unfortunately, we did not evaluate our patient for the presence of HHV-6/7 serum antibodies or plasma DNA during the acute phase of the eruption. 3 , 4 , 5 , 6 Regarding peripheral eosinophilia, our patient had transient eosinophilia with absolute eosinophil count of 880. The presence of eosinophilia might support a drug-induced eruption; however, most of the PR-like eruptions present with normal eosinophil count.…”
mentioning
confidence: 71%